Chemistry: electrical and wave energy – Processes and products
Patent
1986-11-21
1989-06-13
Niebling, John F.
Chemistry: electrical and wave energy
Processes and products
204403, 204405, 204406, 204416, G01N 2746
Patent
active
048390003
ABSTRACT:
A system suitable for determining the concentration of an enzyme's substrate in a solution 21 containing a buffer comprises two ion-sensitive devices 22, 23, such as ISFETS, in contact with the solution, one of the devices 23, e.g. an ENFET, having a layer 24 containing an enzyme, the enzyme producing ions from its substrate, and the system comparing the responses of the two devices and providing a control signal to consume ions as they are generated at the ENFET, or to produce an equal concentration of ions at the other device, such that the concentrations sensed by each are equal. The signal gives an indication of the concentration of the substrate. Other ion-sensitive devices may be used. The concentration of other substances can be determined, for example a device with an enzyme's substrate can be used for detecting the concentration of an enzyme.
REFERENCES:
patent: 3878059 (1975-04-01), Wechter et al.
patent: 4230554 (1980-10-01), Blanke
patent: 4305802 (1981-12-01), Koshiishi
patent: 4312715 (1982-01-01), Albery et al.
"Field Effect Transistor Sensitive to Penicillin", by Steve Caras & J. Janata, Anal. Chem. 1980, 52, pp. 1935-1937.
"Chemical Sensors", by Y. Miyahara, et al., Analytical Chemistry Symposia Series, vol. 17 (1983), pp. 501-506.
"Response of an Enzyme-Modified pH-Sensitive Ion Selective Device; Consideration of the Influence of the Buffering Capacity of the Analyte Solution", by M. j. Eddowes, Sensors and Actuators 7 (1985), pp. 97-115.
"Response of an Enzyme-Modified pH-Sensitive Ion-Selective Device; Experimental Study of a Glucose Oxidase-Modified Ion-Sensitive Field Effect Transistor in Buffered and Unbuffered Aqueous Solution", by M. J. Eddowes, et al., Sensors and Actuators 7 (1985), pp. 233-244.
"pH-Based Enzyme Potentiometric Sensors. Part 1. Theory", by Steve D. Caras and J. Janata, Anal. Chem. 57 (1985), pp. 1917-1925.
"Chemical-sensitive field-effect transistors", by A. Sibbald, IEE Proceedings, vol. 130 Pt. 1, No. 5, Oct. 1983, pp. 233-244.
"Chemically sensitive field-effect transistors", by J. Janata and Stanley D. Moss, S. D., Biomedial Engineering, Jul. 1976, pp. 241-245.
"Coulometric Flow Analyzer for Use with Immobilized Enzyme Reactors", by Robert Adams and Peter Carr, Analytical Chemistry, vol. 50, No. 7, 1978 pp. 944-950.
"An ISFET-Based Microlitre Titrator: Integration of a Chemical Sensor-Actuator System," Van Der Schoot et al., based on paper presented at Third Internat'l. Conference on Solid-State Sensors and Actuators, Philadelphia, PA, Jun. 11-14, 1985, pp. 11-22.
Hsing Ben C.
Niebling John F.
Thorn Emi plc
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