Measuring and testing – Measuring vessel
Patent
1977-12-12
1978-10-03
Swisher, S. Clement
Measuring and testing
Measuring vessel
73 19, G01N 110
Patent
active
041177274
ABSTRACT:
The bubble sensor is embodied in a liquid chromatographic system. In the exemplified system a sample conduit or loop which is already filled with liquid eluent communicates with the bore of a needle. The opening of the needle bore is immersed in a liquid sample so that the sample may be backfilled into the sample loop by the withdrawal of the syringe which communicates with the sample loop. After the liquid sample has been drawn into the sample conduit, the needle is lifted from the sample source and moved toward a final position in which the sample conduit will be placed in parallel with a primary conduit, so that the pump which pumps the liquid eluent will drive the sample from the opening toward the chromatrographic column. As the needle is being raised toward this position, it is stopped at an intermediate position in which the orifice is sealed. In this condition, the liquid sample is within the sample conduit which is part of a closed space between the orifice and the syringe. The syringe is now driven a small distance to reduce the volume of that space by a predetermined, programmed increment. The pressure before and after the change in the space may be compared to indicate the presence or absence of a bubble in the sample. A preferred way of proceeding is to determine the number of incremental changes of predetermined volume to bring the change in pressure up to a predetermined point, for example, 30 psig. If the number of such incremental changes is less than a predetermined number, then it may be presumed that the sample is free of bubble. If the number is greater than the predetermined number, a possible bubble inclusion is indicated and further action may be taken as more fully described hereinafter.
REFERENCES:
patent: 2138141 (1938-11-01), Cromer et al.
patent: 3344656 (1967-10-01), Van Horne et al.
Friswell David R.
Hutchins Burleigh M.
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