BU-3420T Antitumor antibiotic

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...

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435867, 546 34, 514279, C12P 1718, C12R 129, C07D49808, A61K 31395

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active

049160656

ABSTRACT:
The novel antitumor antibiotic designated herein as BU-3420T is produced by fermentation of Micromonospora chersina strain M956-1 (ATCC 53710). BU-3420T and its triacetate derivative possess antibacterial and antifungal activity and also inhibit the growth of mammalian tumors such as P388 leukemia in mice.

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patent: 4675187 (1987-06-01), Konishi et al.
Neckers et al., Organic Chemistry, p. 431, 1977.
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J. Am. Chem. Soc. 109 3466-3468, 1987.
Abstract 227, Program & Abstracts of 26th Interscience Conference on Antimicrobial Agents & Chemotherapy, Sep. 1986.
Abstract No. 984 of 27th Interscience Conf. on Antimicrobial Agents and Chemotherapy (Oct. 4-7, 1987, NYC).
"New Antifungal Antibiotics, Benanomicins A and B from an Antinomycete", J. Antibiotics, 1988, 41(6): 807-811.
"The Structures of New Antifungal Antibiotics, Benanomicins A and B", J. Antibiotics, 1988, 41(8):1019-1028.
Can. J. Chem., 1984, 62:2818-2821.
J. Antibiotics, 1987, 40:1104-1100 and ibid, 1111-1114.

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