Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2007-07-17
2007-07-17
Gambel, Phillip (Department: 1644)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C530S387300
Reexamination Certificate
active
10742682
ABSTRACT:
The invention provides isolated BTL-II proteins, nucleic acids, antibodies, antagonists, and agonists and methods of making and using the same. Diagnostic, screening, and therapeutic methods using the compositions of the invention are provided. For example, the compositions of the invention can be used for diagnosis and treatment of inflammatory bowel diseases and for enhancing a mucosal immune response to an antigen.
REFERENCES:
patent: 5580756 (1996-12-01), Linsley et al.
patent: 2002/0107363 (2002-08-01), Fox et al.
patent: 2002/0156006 (2002-10-01), Ashkenazi et al.
patent: WO 01/53836 (2001-07-01), None
patent: WO 02/00932 (2002-01-01), None
patent: WO 02/057414 (2002-07-01), None
patent: WO 03/070759 (2003-08-01), None
patent: WO 2004/058288 (2004-07-01), None
Attwood, Science, 2000; 290:471-473.
Skolnick et al., Trends in Biotech. 2000; 18(1):34-39.
Metzler et al., Nature Structural Biol., 1997; 4:527-531.
Flower, Trends in Immunology, 2003, vol. 24, pp. 667-674.
Blazar et al., J. Immunol., 1996, 157: 3250-3259.
Beck and Trowsdale, “Sequence organisation of the class II region of the human MHC”J. Imm .Rev.167:201-210, 1999.
Horton, et al., “Large-scale sequence comparisons reveal unusually high levels of variation in theHLA-DQB1locus in the class II region of the human MHC,”J. Mol. Biol.282:71-97, 1998.
Price, et al., “Two major histocompatibility complex haplotypes influence susceptibility to sporadic inclusion body myositis: critical evaluation of an association withHLA-DR3,” Tissue Antigen64:575-580, 2004.
Stammers, et al., “BTL-II: a polymorphic locus with homology to the butyrophilin gene family, located at the border of the major histocompatibility complex class II and class III regions in human and mouse,”Immunogenetics51:373-382, 2000.
Valentonyte, R. et al., “Sarcoidosis is associated with a truncating splice site mutation inBTNL2,” Nat Gene.37(4):357-364, 2005.
NCBI Annotation Project, Accession No. XM 111663, Nov. 2002.
NCBI Annotation Project, Accession No. AF186590, May 2000.
NCBI Annotation Project, Accession No. CAC69895, Sep. 2001.
NCBI Annotation Project, Accession No. NM—019602, Jun. 2001.
NCBI Annotation Project, Accession No. AF050157, Mar. 1998.
NCBI Annotation Project, Accession No. AF186592, May 2000.
NCBI Annotation Project, Accession No. AF186589, May 2000.
NCBI Annotation Project, Accession No. AF186593, May 2000.
NCBI Annotation Project, Accession No. AL662796, Apr. 2002.
NCBI Annotation Project, Accession No. XM—139886, May 2002.
NCBI Annotation Project, Accession No. XM—111663, Nov. 2002.
NCBI Annotation Project, Accession No. XM—113493, May 2002.
NCBI Annotation Project, Accession No. CAB38473, Sep. 2001.
NCBI Annotation Project, Accession No. AF186588, May 2000.
NCBI Annotation Project, Accession No. AF186590, May 2000.
NCBI Annotation Project, Accession No. AF186591, May 2000.
NCBI Annotation Project, Accession No. AF186592, May 2000.
NCBI Annotation Project, Accession No. AF008353, May 2000.
Bowie, J. et al., “Deciphering the message in protein sequences: Tolerance to amino acid substitutions,”Science247:1306-1310, 1990.
Zurawski, S. et al., “Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor,”EMBO J.12(13):5113-5119, 1993.
T. Hunkapiller and L. Hood, “Diversity of the immunoglobulin gene superfamily,”Adv. Immunol., 44:1-63, 1989.
S. Ikemizu et al., “Structure and dimerization of a soluble form of B7-1,”Immunity, 12:51-60, 2000.
P. Olins et al., “Saturation mutagenesis of human interleukin-3,”J. Biol. Chem., 270(40):23754-23760, 1995.
A. Sharpe and G. Freeman, “The B7-CD28 superfamily,”Nature Rev. Immunol., 2:116-126, 2002.
J. Zou et al., “Structure-function analysis of the p35 subunit of mouse interleukin 12,”J. Biol. Chem., 270(11):5864-5871, 1995.
Rhodes, D. A. et al., “The cluster of BTN genes in the extended major histocompatibility complex,”Genomics, 71(3):351-362, 2001.
Baum Peter R.
Escobar Sabine S.
Viney Joanne L.
Gambel Phillip
Immunex Corporation
Ouspenski Ilia
Sweeney Rosemary
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