BTK inhibitors and methods for their identification and use

Details BTK inhibitors and methods for their identification and use BTK inhibitors and methods for their identification and use

1999-07-22

2000-12-12

O'Sullivan, Peter

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

5142385, 514331, 514428, 514548, 544163, 546230, 548567, 558392, 560250, A61K 31535, A61K 31445, A61K 3140, A61K 31275, A61K 31225

Patent

active

061600105

ABSTRACT:
The invention provides BTK inhibitors, methods for their identification and use, and pharmaceutical compositions comprising BTK inhibitors.

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Ahluwalia, V. et al., "Formation of 4-Ethylcoumarins from .beta.-Diketones-Reaction Mechanism", Indian Journal of Chemistry, vol. 15B, pp. 240-241 (1977).
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Ghosh, S. et al., ".alpha.-Cyano-.beta.-hydroxy-.beta.methyl-N-[4-(trifluoromethoxy)phenyl]P ropenamide: An Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase with Potent Cytotoxic Activity against Breast Cancer Cells", Clinical Cancer Research, vol. 4, pp. 2657-2668 (Nov. 1998).
Mahajan, S. et al., "Rational Design and Synthesis of a Novel Anti-leukemic Agent Targeting Bruton's Tyrosine Kinase (BTK), LFM-A13 [.alpha.-Cyano-.beta.-Hydroxy-.beta.-Methyl-N-(2,5-Dibromopheynl)Propenami de]", Journal of Biological Chemistry, vol. 274, No. 14, pp. 9587-9599 (Apr. 2, 1999).
Rehse, K. et al., "Coumarin Derivatives Related to Calophylloid", Arch Pharm., vol. 311, No. 1, pp. 52-58, Abstract only (1978).

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