Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2007-04-17
2007-04-17
Mondesi, Robert B. (Department: 1652)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C435S069100, C536S023100
Reexamination Certificate
active
11489644
ABSTRACT:
The invention relates to Bt toxin resistance management. The invention particularly relates to the isolation and characterization of nucleic acid and polypeptides for a novel Bt toxin receptor. The nucleic acid and polypeptides are useful in identifying and designing novel Bt toxin receptor ligands including novel insecticidal toxins.
REFERENCES:
patent: 5693491 (1997-12-01), Bulla et al.
patent: 5804393 (1998-09-01), Geiser et al.
patent: 6007981 (1999-12-01), Bulla
patent: 1 124 426 (2003-01-01), None
patent: WO 96/12964 (1996-02-01), None
patent: WO 98/59048 (1998-12-01), None
patent: WO 01/34807 (2001-05-01), None
patent: WO 01/36639 (2001-05-01), None
patent: WO 02/074079 (2002-09-01), None
Dorsch, J.A., “Isolation and Characterization of the Insecticidal Toxin Binding Site From the Receptor BT-r1ofManduca sexta,” May 1998, A dissertation submitted to the Department of Molecular Biology and the Graduate School of the University of Wyoming, Laramie, Wyoming.
Dorsch, J.A., et al., “CRYlA Toxins ofBacillus thuringiensisbind specifically to a region adjacent to the membrane-proximal extracellular domain of BT-R1inManduca sexta: involvement of a cadherin in the entomopathogenicity ofBacillus thuringiensis,” Insect Biochemistry and Molecular Biology, 2002, pp. 1025-1036, vol. 32.
Estruch, J.J., et al., “Transgenic plants: An emerging approach to pest control,”Nature Biotechnology, Feb. 1997, pp. 137-141, vol. 15.
Francis, B.R., and Bulla, L.A., Jr., “Further Characterization of BT-R1, the Cadherin-like Receptor for CrylAb Toxin in Tobacco Hornworm (Manduca Sexta) Midguts,”Insect Biochem. Molec. Biol., 1997, pp. 541-550, vol. 27, No. 6.
Franklin, S.W., et al., “Southern analysis of BT-R1, theManduca sextagene encoding the receptor for the CrylAb toxin ofBacillus thuringiensis,” Mol Gen Genet, 1997, pp. 517-524, vol. 256.
Gahan, J.L., et al., “Identification of a Gene Associated with Bt Resistance inHeliothis virescens,” Science, Aug. 3, 2001, pp. 857-860, vol. 293.
Garczynski, S.F., et al., “Identification of Putative Insect Brush Border Membrane-Binding Molecules Specific toBacillus thuringiensisδ-Endotoxin by Protein Blot Analysis,”Applied and Environmental Microbiology, Oct. 1991, pp. 2816-2820, vol. 57, No. 10.
Gill, S.S., et al., “Identification, Isolation, and Cloning of aBacillus thuringiensisCrylAc Toxin-binding Protein from the Midgut of the Lepidopteran InsectHeliothis virescens,” The Journal of Biological Chemistry, Nov. 10, 1995, pp. 27277-27282, vol. 270, No. 45.
Hofte, H. and Whiteley, H.R., “Insecticidal Crystal Proteins ofBacillus thuringiensis,” Microbiological Reviews, Jun. 1989, pp. 242-255, vol. 53, No. 3.
Hua, G., et al., “Binding Analyses ofBacillus thuringiensisCry δ-Endotoxins Using Brush Border Membrane Vesicles ofOstrinia nubilalis,” Applied and Environmental Microbiology, Feb. 2001, pp. 872-879, vol. 67, No. 2.
Ihara, H., et al., “Purification and partial amino acid sequences of the binding protein frombombys morifor CrylAa δ-endotoxin ofBacillus thuringiensis,” Comparative Biochemistry and Physiology, Part B, 1998, pp. 197-204, vol. 120.
Jurat-Fuentes, J.L., et al., “Altered Glycosylation of 63-68-Kilodalton Microvillar Proteins inHeliothis virescensCorrelates with Reduced Cryl Toxin Binding, Decreased Pore Formulation, and Increased Resistance toBacillus thuringiensisCryl Toxins,”Applied and Environmental Microbiology, Nov. 2002, pp. 5711-5717, vol. 68, No. 11.
Keeton, T.P., and Bulla, L.A., Jr., “Ligand Specificity and Affinity of BT-R1, theBacillus thuringiensisCrylA Toxin Receptor fromManduca sexta, Expressed in Mammalian and Insect Cell Cultures,”Applied and Environmental Microbiology, Sep. 1997, pp. 3419-3425, vol. 63, No. 9.
Keeton, T.P., et al., “Effects of Midgut-Protein-Preparative and Ligand Binding Procedures on the Toxin Binding Characteristics of BT-R1, a Common High-Affinity Receptor inManduca sextafor CrylABacillus thuringiensisToxins,”Applied and Environmental Microbiology, Jun. 1998, pp. 2158-2165, vol. 64, No. 6.
Knight, P.J.K., et al., “The receptor ofBacillus thuringiensisCrlA(c) delta-endotoxin in the brush border membrane of the lepidopteranManduca sextais aminopeptidase N,”Molecular Microbiology, 1994, pp. 429-436, vol. 11, No. 3.
Nakanishi, K., et al., “Aminopeptidase N Isoforms from the Midgut ofBombyx moriandPlutella xylostella—Their Classification and the Factors that Determine Their Binding Specificity toBacillus thuringiensisCrylA Toxin,”FEBS Letters, May 22, 2002, pp. 215-220, vol. 519, No. 1-3.
Lee, M.K. et al., “Aminopeptidase N Purified from Gypsy Moth Brush Border Membrane Vesicles is a Specific Receptor forBacillus thuringiensisCrylAc Toxin,”Applied and Environmental Microbiology, Aug. 1996, pp. 2845-2849, vol. 62, No. 8.
Maaty, W.S.A., “Identification, Purification and Cloning of a High-Affinity Invertebrate Protocadherin Receptor BT-R2from the Pink Bollworm (Pectinophora Gosspiella) forBacillus ThuringiensisCRYlA Toxins,” Dissertation submitted to the Dept. of Molecular Biology and The Graduate School of the University of Wyoming, Jul. 1999, pp. 1-146.
McGaughey, W.H., et al., “Bt resistance management—A plan for reconciling the needs of the many stakeholders in Bt-based products,”Nature Biotechnology, Feb. 1998, pp. 144-146, vol. 16.
Midboe, E.G., “Characterization of the BT-R1Gene and Its Expression inManduca sexta,” Dissertation submitted to the Dept. of Molecular Biology and The Graduate School of the University of Wyoming, Jul. 1999, pp. 1-135.
Nagamatsu, Y., et al., “Cloning, Sequencing, and Expression of theBombyx moriReceptor forBacillus thuringiensisInsecticidal CrylA(a) Toxin,”Biosci. Biotechnol. Biochem., 1998, pp. 727-734, vol. 62, No. 4.
Nagamatsu, Y., et al., “The cadherin-like protein is essential to specificity determination and cytotoxin action of theBacillus thuringiensisinsecticidal CrylAa toxin,”FEBS Letters, 1999, pp. 385-390, vol. 460.
Oddou, P., et al., “Immunologically unrelatedheliothissp. AndSpodopterasp. Midgut membrane-proteins bindBacillus thuringiensisCrylA(b) δ-endotoxin,”Eur. J. Biochem., 1993, pp. 145-150, vol. 212.
Roush, R.T., and Shelton, A.M., “Assessing the odds: The emergency of resistance to Bt transgenic plants,”Nature Biotechnology, Sep. 1997, pp. 816-817, vol. 15.
Rudinger, J., “Characteristics of the amino acids as components of a peptide hormone sequence,”Peptide Hormones,Jun. 1976, pp. 1-7, J. A. Parsons, Editor; University Park Press, Baltimore.
Skolnick, J. and Fetrow, J.S., “From genes to protein structure and function: novel applications of computational approaches in the genomic era,”Trends in Biotechnology, 2000, pp. 34-39, vol. 18, No. 1.
Vadlamudi, R.K., et al., “A Specific Binding Protein frommanduca sextafor the Insecticidal Toxin ofBacillus thuringiensissubsp. berliner,”J. Biol. Chem., Jun. 15, 1993, pp. 12334-12340, vol. 268, No. 17.
Vadlamudi, R.K. et al., “Cloning and Expression of a Receptor for an Insecticidal Toxin ofBacillus thuringiensis,”J. Biol. Chem., Mar. 10, 1995, pp. 5499-5494, vol. 270, No. 10.
Alston & Bird LLP
Mondesi Robert B.
Pioneer Hi-Bred International , Inc.
LandOfFree
Bt toxin receptors and methods of use does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Bt toxin receptors and methods of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bt toxin receptors and methods of use will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3746330