Bsk receptor-like tyrosine kinase

Details Bsk receptor-like tyrosine kinase Bsk receptor-like tyrosine kinase

1996-06-11

1998-09-29

Walsh, Stephen

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435194, 435325, 435348, 4352523, 43525411, 4353201, 536 235, 536 232, 536 2431, C12N 1512, C12N 1552

Patent

active

058144790

ABSTRACT:
The present invention provides a nucleic acid sequence encoding a receptor-like tyrosine kinase designated, Bsk. The Bsk receptor-like tyrosine kinase is expressed predominantly in the brain, specifically the limbic system. Also included is the receptor encoded by the Bsk nucleic acid sequence and antibodies reactive with the Bsk protein. This invention further relates to bioassays using the nucleic acid sequence, receptor protein or antibodies of this invention to diagnose, assess, or prognose a mammal afflicted with neurodegenerative disease. Therapeutic uses for the Bsk receptor-like tyrosine kinase are also provided. This invention also relates to the ligand for the Bsk receptor, and diagnostic and therapeutic uses for the Bsk ligand.

REFERENCES:
Barinaga, Science, vol. 264, p. 772, 1994.
Maisonpierre, Peter C., et al.; "Ehk-1 and Ehk-2: Two Novel Members Of The Eph Receptor-Like Tyrosine Kinase Family With Distinctive And Neuronal Expression"; Ongogene, (1993), vol. 8, pp. 3277-3288.
Maru, Y. et al., "Evolution, Expression, and Chromosomal Location of a Novel Receptor Tyrosine Kinase Gene, eph." Mol. and Cell Biology, 8:3770-3776 (1988).
Sajjadi, F.G., et al., "Identification of a New eph-Related Receptor Tyrosine kinase Gene From Mouse and Chicken That is Developmentally Regulated and Encodes at Least Two Forms of the Receptor", The New Biologist 3:769-778 (1991).
Lindberg, R.A. and Hunter, T. "cDNA Cloning and Characterization of eck, an Epithelial Cell Receptor Protein-Tyrosine kinase in the eph/elk Family of Protein Kinases" Mol. and Cell. Biology 10:6316-6324 (1990).
Lhotak, V. et al., "Characterization of Elk, a Brain-Specific Receptor Tyrosine Kinase", Mol and Cell Biology 11:2496-2502 (1991).
Gilardi-Hebenstreit, P. et al., "An Eph-Related Receptor Protein Tyrosine Kinase Gene Segmentally Expressed in the Developing Mouse Hindbrain", Oncogene 7:2499-2506 (1992).
Saijadi, F.G. and Pasquale, E.B., "Five Novel Eph-related Tyrosine Kinases are Differently Expressed", Oncogene, 8:1807-1813 (1993).
Pasquale "Identification of Chicken Embryo Kinase 5, a Developmentally Regulated Receptor-Type Tyrosine Kinase of the Eph Family" Cell Regulation 2:523-534 (1991).
Chan And Watt "Eek and Erk, New Members of the Eph Subclass of Receptor Protein-Tyrosine Kinases" Oncogene 6:1057-1061 (1991).
Hirai et al., "A Novel Putative Tyrosine Kinase Receptor Ecoded by the Eph Gene" Science 238:1717-1720 (1987).
Wicks et al., "Molecular Cloning of Hek, the Gene Encoding a Receptor Tyrosine Kinase Expressed by Human Lymphoid Tumor Cell Lines" Proc. Natl. Acad. Sciences (USA) 89:1611-1615 (1992).
Nieto et al., "A Receptor Protein Tyrosine Kinase Implicated in the Segmental Patterning of the Hindbrain and Mesoderm" Development 116:1137-1150 (1992).

Affiliated with

Also associated with

Rating

Bsk receptor-like tyrosine kinase does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bsk receptor-like tyrosine kinase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bsk receptor-like tyrosine kinase will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-685382