Bryostatins 4 to 8

Details Bryostatins 4 to 8 Bryostatins 4 to 8

1984-08-10

1986-09-09

Fan, Jane T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D49322

Patent

active

046110666

ABSTRACT:
New and potent antineoplastic agents designated bryostatin 4, bryostatin 5, bryostatin 6, bryostatin 7, and bryostatin 8 have been isolated from the marine animal Bugula neritina L. and Amatnea convoluta (Bryozoan phylum).

REFERENCES:
Pettit, G. R., et al., Nature, 1970, 227:962-963.
Villela, G. G., Proc. Soc. Exptl. Biol. Med., 1948, 68:531-553.
Carle', J. S., et al., J. Org. Chem., 1980, 45:1586-1589; 1981, 46:3440-3448.
Okami, Y., et al., J. Antibiot., 1976, 29:1019.
Nakamura, H., et al., J. Antibiot., 1977, 3.0;714.
Copending application Ser. No. 513,148, filed 12 Jul. 1983.

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