Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2008-05-20
2008-05-20
Helms, Larry R. (Department: 1643)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023100, C435S006120
Reexamination Certificate
active
07375206
ABSTRACT:
An isolated or purified nucleic acid molecule consisting essentially of a nucleotide sequence encoding a human or a non-human BORIS, or a fragment of either of the foregoing; an isolated or purified nucleic acid molecule consisting essentially of a nucleotide sequence that is complementary to a nucleotide sequence encoding a human or a non-human BORIS, or a fragment of either of the foregoing; a vector comprising such an isolated or purified nucleic acid molecule; a cell comprising such a vector; an isolated or purified polypeptide molecule consisting essentially of an amino acid sequence encoding a human or a non-human BORIS, or a fragment of either of the foregoing; a cell line that produces a monoclonal antibody that is specific for an aforementioned isolated or purified polypeptide molecule; and the monoclonal antibody produced by the cell line; methods of diagnosing a cancer or a predisposition to a cancer in a male or female mammal; a method of prognosticating a cancer in a mammal; a method of assessing the effectiveness of treatment of a cancer in a mammal; a method of treating a mammal prophylactically or therapeutically for a cancer, and a composition comprising a carrier and an inhibitor of BORIS.
REFERENCES:
patent: 5279721 (1994-01-01), Schmid
patent: 5801030 (1998-09-01), McVey et al.
patent: 5837511 (1998-11-01), Falck-Pedersen et al.
patent: 5849561 (1998-12-01), Falck-Pedersen
patent: 5972643 (1999-10-01), Lobanenkov et al.
patent: WO 97/12986 (1997-04-01), None
patent: WO 98/53087 (1998-11-01), None
patent: WO02074913 (2002-09-01), None
Skolnick, J. and Fetrow, J.S. From genes to protein structure and function: novel applications of computational approaches in the genomic era. 2000. Trends in Biotechnology. vol. 18 No. 1, pp. 34-39.
Burgess, Shaheen, Ravera, Jaye, Donahue, and Winkles Possible dissociation of the heparin-binding and mitogenic activities of heparin-binding (acidic fibroblast) growth factor-1 from its receptor-binding activites by site-directed mutagenesis of a single lysine residue. 1990. Journal of Cell Biology, vol. 111, pp. 2129-2138.
Lazar, E., Watanabe, S., Dalton, S., andd Sporn, M.B. Transforming growth factor a: mutation of aspartic acid 47 and leucine 48 results in different biological activities. 1988. Molecular and Cellular Biology, vol. 8 No. 3, pp. 1247-1252.
Schwartz, G.P., Burke, G.T., and Katsoyannis, P.G. A superactive insulin: [B10-aspartic acid] insulin (human). 1987. Proceedings of the National Academy of Sciences, vol. 84, pp. 6408-6411.
Lin, M.C., Wright, D.E., Hruby, V.J., and Rodbell, M. Structure-function relationships in glucagon: properties of highly purified Des-His1-, Monoiodo-, and [Des-Asn28, Thr29](homoserine lactone27)-glucagon. 1975. Biochemistry, vol. 14, pp. 1559-1563.
Freshney, R.I. Culture of Animal Cells, Alan R. Liss, Inc. 1983. New York. p. 4.
Dermer, G.B. Another anniversary for the war on cancer. 1994. Biotechnology, vol. 12, p. 320.
Galcheva-Gargova, Z., Konstantinov, K.N., Wu, I., Klier, F.G., Barrett, T., and Davis, R.J. Binding of zinc finger protein ZPR1 to the epidermal growth factor receptor. 1996. Science, vol. 272, pp. 1797-1802.
Klenova et al.,Seminars in Cancer Biology, 12, 399-414 (2002).
Loukinov et al.,PNAS, 99(10), 6806-6811, (May 14, 2002).
D'Arcy et al., “The Potential of BORIS Detected in the Leukocytes of Breast Cancer Patients as an Early Marker of Tumorigenesis,”Clin. Cancer Res., 12(20), pp. 5978-5986, (Oct. 15, 2006).
Risinger et al., “Global Expression Analysis of Cancer/Testis Genes in Uterine Cancers Reveals a High Incidence of BORIS Expression,”Clin. Cancer Res., 13 (6), pp. 1713-1719, (Mar. 15, 2007).
Adair et al.,Proc. Natl. Acad. Sci. USA, 86, 4574-4578 (Jun. 1989).
Arnold et al.,Gene, 253, 209-214 (2000).
Awad et al.,J. Biol. Chem., 274 (38), 27092-27098 (1999).
Bell et al.,Cell, 98, 387-396 (Aug. 6, 1999).
Bell et al.,Nature, 405, 482-485 (May 25, 2000).
Bird,Nature, 321, 209-213 (May 15, 1986).
Capecchi,Science, 244, 1288-1292 (Jun. 1989).
Chernukhin et al.,J. Biol. Chem., 275 (38), 29915-29921 (Sep. 22, 2000).
Feinberg,PNAS, 98 (2), 392-394 (Jan. 16, 2001).
Filippova et al.,Mol. Cell. Biol., 16 (6), 2802-2813 (Jun. 1996).
Filippova et al.,Nature Genetics, 28, 335-343 (Aug. 2001).
Filippova et al.,Cancer Research, 62 (1), 48-52 (2002).
GenBank accession # AF313621, Moore et al. (2002).
Hark et al.,Nature, 405, 486-489 (May 25, 2000).
Johnson et al.,Science, 245, 1234-1236 (Sep. 15, 1989).
Kanduri et al.,Current Biology, 10 (14), 853-856 (2000).
Klenova et al.,Mol. Cell Biol., 13 (12), 7612-7624 (Dec. 1993).
Klenova et al.,J. Biol. Chem., 273 (41), 26571-26579 (Oct. 9, 1998).
Klenova et al.,Mol. Cell. Biol., 21 (6), 2221-2234 (Mar. 2001).
Kostic et al.,Oncogene, 19, 3978-3987 (2000).
Lichtsteiner et al.,Cell, 51, 963-973 (Dec. 24, 1987).
Lobanenkov et al.,Oncogene, 5, 1743-1753 (1990).
Lutz et al.,Biochem. Soc. Trans., 28 (4), 386-390 (2000).
Lutz et al.,Nuc. Acids Res., 28 (8), 1707-1713 (2000).
Mansour et al.,Nature, 336, 348-352 (Nov. 1988).
Nakagawa et al.,PNAS, 98 (2), 591-596 (Jan. 16, 2001).
Ohlsson et al.,Trends in Genetics, 17 (9), 520-527 (Sep. 2001).
Pack et al.,Cancer Res., 59, 5560-5564 (Nov. 1, 1999).
Quitschke et al.,Nuc. Acids Res., 28 (17), 3370-3378 (2000).
Rasko et al.,Cancer Res., 61, 6002-6007 (Aug. 15, 2001).
Reik et al.,Nature, 405, 408-409 (May 25, 2000).
Saitoh et al.,EMBO J., 19 (10), 2315-2322 (2000).
Szabo et al.,Curr. Biol., 10 (10), 607-610 (May 2000).
Thorvaldsen et al.,Science, 288, 2145-2146 (Jun. 23, 2000).
Vostrov et al.,J. Biol. Chem., 277 (2), 1619-1627 (Jan. 11, 2002).
Wolffe,Curr. Biol., 10 (11), R463-R465 (2000).
Wylie et al.,Genome Res., 10 (11), 1711-1718 (2000).
Yang et al.,J. Neurochem., 73 (6), 2286-2298 (Dec. 1999).
Zijlstra et al.,Nature, 342, 435-438 (Nov. 1989).
Lobanenkov Victor V.
Loukinov Dmitri I.
Morse, III Herbert C.
Gussow Anne M.
Helms Larry R.
Leydig , Voit & Mayer, Ltd.
The United States of America as represented by the Department of
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