Bromo-tryptophan conopeptides

Details Bromo-tryptophan conopeptides Bromo-tryptophan conopeptides

1997-01-17

1999-03-30

Tsang, Cecilia J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530325, 530326, 530327, 530328, A61K 3808, A61K 3810, A61K 3816, C07K 704

Patent

active

058891471

ABSTRACT:
The present invention is directed to conopeptides having 6-45 amino acids, including one or more bromo-tryptophan residues. More specifically, the present invention is directed to conopeptides having the general formula: R-(Cys).sub.n -R.sup.1 -B-R.sup.2 -Cys-R.sup.3, wherein R is a peptide chain of 0-24 amino acids, R.sup.1 is a peptide chain of 0 to 31 amino acids, R.sup.2 is a peptide chain of 0-29 amino acids, R.sup.3 is a peptide chain of 0 to 26 amino acids, B is 6-bromo-tryptophan, n is 0 or 1 and the total length of the conopeptide is from about 6 to about 45 amino acids. The invention also includes pharmaceutically acceptable salts of the conopeptides. These bromo-tryptophan containing conopeptides invention are useful as antihelminthic agents, anti-vomiting agents, sleep-inducing agents, adjuncts to anesthesia, anticonvulsant or neuroprotective agents.

REFERENCES:
patent: 4224199 (1980-09-01), Meyers
patent: 5064939 (1991-11-01), Rivier
patent: 5371070 (1994-12-01), Koerber
patent: 5750499 (1998-05-01), Hoeger

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