Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-06-07
1997-03-18
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514422, 514464, 514466, 544377, 548526, 549435, A61K 3136, C07D31762, C07D31764, C07D31766
Patent
active
056123418
ABSTRACT:
Disclosed herein are derivatives of 4,4'-dimethoxy-5,6,5'6'-bimethylenedioxy 2,2'-dimethoxycarbonyl biphenyl (DDB) which were synthesized and found to have anti-HIV activity. Of the compounds studied, 3,3'-dibromo DDB and 3-bromo-DDB initially exhibited the greatest anti-HIV activity.
REFERENCES:
patent: 4849448 (1989-07-01), Kimura et al.
patent: 4868207 (1989-09-01), Shi-jie
patent: 4904694 (1990-02-01), Matsuoka et al.
patent: 4987240 (1991-01-01), Matsuoko et al.
patent: 4996331 (1991-02-01), Kimura et al.
patent: 5103023 (1992-04-01), Iwasaki et al.
patent: 5159069 (1992-10-01), Hirayama et al.
patent: 5182404 (1993-01-01), Iwasaki et al.
patent: 5233057 (1993-08-01), Iwasaki et al.
patent: 5264594 (1993-11-01), Kimura et al.
Cardellina, J.H., II, et al., "A Chemical Screening Strategy for the Dereplication and Prioritization of HIV-Inhibitory Aqueous Natural Products Extracts," J. Natural Prod. 56(7):1123-1129 (Jul. 1993).
Gengtao, L., "Hepato-Pharmacology of Fructus schizandrae," in: Advances in Chinese Medicinal Materials Research, Chang, H.M., et al., Eds., Singapore: World Scientific Publ. Co., pp. 257-267 (1985).
Kakiuchi, N., et al., "Inhibitory Effect of Tannins on Reverse Transcriptase from RNA Tumor Virus," J. Natural Prod. 48(4):614-621 (1985).
Kashiwada, Y., et al., "New Hexahydroxydiphenyl Derivatives as Potent Inhibitors of HIV Replication in H9 Lymphocytes," Bioorg. Med. Chem. Letts. 2(3):235-238 (1992).
Kashiwada, Y., et al., "New Hexahydroxybiphenyl Derivatives as Inhibitors of Protein Kinase C," J. Med. Chem. 37(1):195-200 (Jan. 7, 1994).
Nakashima, H., et al., "Inhibition of Human Immunodeficiency Viral Replication by Tannins and Related Compounds," Antiviral Res. 18:91-103 (1992).
Nonaka, G.-I., et al., "Anti-AIDS Agents, 2: Inhibitory Effects of Tannins on HIV Reverse Transcriptase and HIV Replication in H9 Lymphocyte Cells," J. Natural Prod. 53(3):587-595 (1990).
Okuda, T., et al., "Ellagitannins as Active Constituents of Medicinal Plants," Planta Medica 55:117-122 (1989).
Yi et al. (CA 108:204530f), 1988.
Huff, J. Med. Chem. vol. 34, No. 8, Aug. 1991, pp. 2305-2314.
Cheng Yung-Chi
Cosentino Louis M.
Kashiwada Yoshiki
Kilkulskie Robert
Lee Kuo-Hsiung
Biotech Research Laboratories
Richter Johann
Stockton Laura L.
University of North Carolina at Chapel Hill
LandOfFree
Brominated hexahydroxybiphenyl derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Brominated hexahydroxybiphenyl derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Brominated hexahydroxybiphenyl derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1706531