Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2007-05-29
2007-05-29
Campell, Bruce R. (Department: 1648)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S350000, C530S380000, C530S386000, C530S387100, C530S388100, C530S388150, C530S388220, C530S388350, C435S332000, C435S334000, C435S339100, C424S142100, C424S148100, C424S159100, C424S160100, C424S178100
Reexamination Certificate
active
10492729
ABSTRACT:
The present invention features antibodies and antibody fragments that specifically bind a CD4-inducible HIV gp120 epitope that is enhanced by binding a co-receptor for HIV, such as CCR5 or CXCR4, and pharmaceutical compositions comprising the antibodies or antibody fragments. The invention also features nucleic acids encoding the antibodies or antibody fragments, pharmaceutical compositions comprising the nucleic acids encoding the antibodies or antibody fragments, vectors comprising the nucleic acids, and cells comprising the vectors. The invention further features methods of identifying antibodies or antibody fragments with broadly neutralizing activity against HIV. The invention also features methods of inhibiting HIV entry into cells and methods of inhibiting replication of HIV in mammals, using the antibodies and nucleic acids of the invention.
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Burton Dennis
Dimitrov Dimiter S.
Moulard Maxime
Phogat Sanjay K.
Shu Yuuei
Campell Bruce R.
Kinsey Nicole
Leydig , Voit & Mayer, Ltd.
Scripps Research Institute
United States of America, Represented by the Secretary, Departme
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