Broad spectrum pyrogenic exotoxins antagonists and vaccines

Details Broad spectrum pyrogenic exotoxins antagonists and vaccines Broad spectrum pyrogenic exotoxins antagonists and vaccines

2007-03-13

2007-03-13

Navarro, Mark (Department: 1645)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

C424S185100, C424S193100, C424S234100, C424S235100, C424S236100, C424S237100, C424S244100, C435S243000, C435S253400, C530S300000, C530S350000

Reexamination Certificate

active

09150947

ABSTRACT:
The invention relates to peptides having an amino acid sequence substantially homologous to an amino sequence of a domain of a pyrogenic exotoxin, which domain forms a central turn in the exotoxin starting within β-strand 7 and connecting the β-strand 7, via short β-strand 8, to α-helix 4, and ending within α-helix 4, based on the domain numbering ofStaphylococus aureusenterotoxin B. The peptides of the invention are capable of antagonizing toxin-mediated activation of T-lymphocytes, do not have agonist activity, and are capable of eliciting protective immunity against toxic shock induced by a pyrogenic exotoxin or by a mixture of pyrogenic exotoxins. The invention also relates to broad spectrum pharmaceutical compositions for the treatment, protection against or short term prophylaxis of toxin-mediated activation of T cells, comprising as active ingredient at least one peptide according to the invention or a derivative thereof, and to broad spectrum vaccines for conferring long term immunity against toxic shock induced by at least one pyrogenic exotoxin.

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