Broad spectrum antimicrobial compounds and methods of use

Details Broad spectrum antimicrobial compounds and methods of use Broad spectrum antimicrobial compounds and methods of use

1991-06-14

1994-06-28

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 530324, 530327, A61K 3700, A61K 3702, C07K 500, C07K 700

Patent

active

053247167

ABSTRACT:
The invention provides a broad spectrum antimicrobial compound that includes a tryptophan-rich peptide exhibiting antimicrobial activity. A method of microbicidal inhibition or microbistatic inhibition of microbial growth is also provided. The method includes administering to an environment capable of sustaining microbial growth a microbicidally or microbistatically effective amount of a tryptophan-rich peptide exhibiting antimicrobial activity.

REFERENCES:
patent: 4543252 (1985-09-01), Lehrer et al.
Diamond et al., "Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: Peptide isolation and cloning of a cDNA" Proc. Natl. Acad. Sci. USA 88:3952-3956 (1991).
Boman, Hans G., "Antibacterial Peptides: Key Components Needed in Immunity" Cell 65:205-207 (1991).
Zanetti et al., "Bactenecins, Defense Polypeptides of Bovine Neutrophils, Are Generated from Precursor Molecules Stored in the Large Granules" The Journal of Cell Biology 111:1363-1371 (1990).
Selsted et al., "Purification and Antibacterial Activity of Antimicrobial Peptides of Rabbit Granulocytes" Infection and Immunity 45:150-154 (1984).
Frank et al., J. of Biol Chem., vol. 265, No. 31, pp. 18871-18874, 1990.
Nagalakskmi et al., Chem. Abstrs., vol. 101, p. 492, Ab No. 22133b, 1984.
Fox et al., Chem. Abstrs., vol. 107, p. 529, Abst No. 233726j, 1987.
Shimokawa et al., Chem. Abstrs, vol. 114, p. 406, Abst No. 235045e, 1991.

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