Broad spectrum antimicrobial compounds and methods of use

Details Broad spectrum antimicrobial compounds and methods of use Broad spectrum antimicrobial compounds and methods of use

1994-02-16

1996-08-20

Warden, Jill

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 530324, 530327, 426326, 426335, 510382, 510383, 422 28, 210764, 424405, A61K 3800, C07K 500, C07K 700, C07K 1700

Patent

active

055479391

ABSTRACT:
The present invention provides indolicidin analogs, which are tryptophan-rich peptides that have substantially the same amino acid sequence as naturally occurring indolicidin, exhibit broad spectrum antimicrobial activity and have antimicrobial selectivity as compared to naturally occurring indolicidin. The invention also provides methods of using an indolicidin analog to inhibit or prevent the survival or growth of a microorganism in an environment capable of sustaining such survival or growth. The invention provides, for example, methods of administering an effective amount of an indolicidin analog to an environment capable of sustaining the survival or growth of a microorganism.

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