Bridged ring NK 1 antagonists

Details Bridged ring NK 1 antagonists Bridged ring NK 1 antagonists

2008-04-08

2008-04-08

Seaman, Margaret D. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C540S460000, C544S349000

Reexamination Certificate

active

07354922

ABSTRACT:
A compound having the general structure shown in Formula (I):or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.

REFERENCES:
patent: 5620989 (1997-04-01), Harrison et al.
patent: 5661162 (1997-08-01), MacLeod et al.
patent: 5760018 (1998-06-01), Baker et al.
patent: 6329401 (2001-12-01), Mendel et al.
West, Anthony R., Solid State Chemistry and its Applications, Wiley, New York, 1988, pp. 358 & 365.
Ahmed et al., Journal of Medicinal Chemistry, 1976, vol. 19, pp. 117-122.
Saria et al., European Journal of Pharmacology, 1999, vol. 375, pp. 51-60.
Wu, X., et al., “Generation of Cyclopenta[c]piperidines and Pyrrolo(3,4-c)piperidines-Potential Substance P Antagonists-from Adducts of Cyclic Dienophiles and 5-Chloro-6-methyl-3-phenyl-2H-1,4-oxazin-2-one”, Tetrahedron, 56, 6279-6290 (2000).
Rombouts, F., et al. “Synthesis and conformational analysis of Substance P antagonist analogues based on a 1,7-nephthyridine scaffold”, Tetrahedron, 59, 4721-4731 (2003).
PCT International Search Report dated Mar. 30, 2006 for Corresponding PCT Application No. PCT/US2005/044647.

Affiliated with

Also associated with

Rating

Bridged ring NK 1 antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bridged ring NK 1 antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bridged ring NK 1 antagonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2785077