Bridged N-cyclic sulfonamido inhibitors of gamma secretase

Details Bridged N-cyclic sulfonamido inhibitors of gamma secretase Bridged N-cyclic sulfonamido inhibitors of gamma secretase

2006-08-18

2008-03-18

Andres, Janet (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C540S477000, C546S124000, C546S112000

Reexamination Certificate

active

07345056

ABSTRACT:
The invention provides N-cyclic sulfonamido compounds and salts of Formula I:wherein A is as described in the specification and R1and R2combine to form a [3.3.1] or a [3.2.1] ring system, where the nitrogen is attached to the two bridgehead carbons, and the [3.3.1] or [3.2.1] ring systems are optionally fused with an heteroaryl or heterocycloalkyl ring. Compounds of Formula I are useful in treating or preventing cognitive disorders, such as Alzheimer's Disease. The invention also encompasses pharmaceutical compositions comprising compounds of Formula I, methods of treating cognitive disorders, such as Alzheimer's disease, and the intermediates useful in preparing the compounds of Formula I.

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