Bridged-bis-hydroxyamide dicarbanilates

Details Bridged-bis-hydroxyamide dicarbanilates Bridged-bis-hydroxyamide dicarbanilates

1978-06-16

1979-02-20

Thomas, Jr., James O.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C07C12506, A61K 3127

Patent

active

041408608

ABSTRACT:
N,N'-Bridged-bis[(O and/or N-substituted)-2-alkyl-2-hydroxyethylamines] of the formula ##STR1## are prepared by condensing an epoxide of the formula ##STR2## and a diamine of the formula R'NH--X--NHR'. The products and dicarbanilates, acid-addition salts, N,N'-dioxides and N,N'-diammonium quaternary salts derived therefrom have antibacterial activity in vitro and are useful as antibacterial agents.

REFERENCES:
patent: 3524883 (1970-08-01), Kersnar et al.
Sterling, Chem. Absts., 84, 164137(k), 1976.

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