Bridged bicyclic serine protease inhibitors

Details Bridged bicyclic serine protease inhibitors Bridged bicyclic serine protease inhibitors

2005-06-21

2005-06-21

Kumar, Shailendra (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C548S312100, C548S452000, C548S515000, C514S255050, C514S397000, C514S412000, C514S413000

Reexamination Certificate

active

06909000

ABSTRACT:
The present invention relates to peptidomimetic compounds which inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The compounds of this invention have a bridged bicyclic moiety at the P2 position. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention.

REFERENCES:
patent: 4720484 (1988-01-01), Vincent et al.
patent: 6265380 (2001-07-01), Tung et al.
patent: WO 97/43310 (1997-11-01), None
patent: WO 98/17679 (1998-04-01), None
patent: WO 98/46630 (1998-10-01), None
patent: WO 99/07733 (1999-02-01), None
patent: WO 99/07734 (1999-02-01), None
patent: WO 99/50230 (1999-10-01), None
patent: WO 99/64442 (1999-12-01), None
patent: WO 00/09543 (2000-02-01), None
patent: WO 00/09558 (2000-02-01), None
patent: WO 01/74768 (2001-10-01), None
patent: WO 02/08244 (2002-01-01), None
LaPlante, S.R., et al., “NMR Line-Broadening and Transferred NOESY as a Medicinal Chemistry Tool for Studying Inhibitors of the Hepatits C Virus NS3 Protease Domain,”Bioorg.&Med. Chem. Ltrs.,10:2271-2274 (2000).
Llinàs-Brunet, M., et al., “Highly Potent and Selective Peptide-Based Inhibitors of the Hepatitis C Virus Serine Protease: Towards Smaller Inhibitors,”Bioorg.&Med. Chem. Ltrs.,10:2267-2270 (2000).
Dunsdon, R. M., et al., “Solid Phase Synthesis of Aminoboronic Acids: Potent Inhibitors of the Hepatitis C Virus NS3 Proteinase,”Bioorg.&Med. Chem. Ltrs.,10:1577-1579 (2000).
Han, W., et al., “α-Ketoamides, α-Ketoesters and α-Diketones as HCV NS3 Protease Inhibitors,”Bioorg.&Med. Chem. Ltrs.,10:711-713 (2000).
Llinàs-Brunet, M., et al., “Peptide-Based Inhibitors of the Hepatitis C Virus Serine Protease,”Bioorg.&Med. Chem. Ltrs.,8:1713-1718 (1998).

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