Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Patent
1992-11-25
1995-11-14
Dees, Jose G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
562490, C07C 6976, C07C 6336
Patent
active
054668611
ABSTRACT:
Bridged bicyclic aromatic compounds are provided having the structure ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and n are as defined herein. The novel compounds are useful for modulating gene expression of retinoic acid receptors, vitamin D receptors and thyroid receptors. Pharmaceutical compositions and methods for modulating gene expression are provided as well.
REFERENCES:
patent: 4689436 (1987-08-01), Minokami et al.
patent: 4808631 (1989-02-01), Klaus
patent: 4826969 (1989-05-01), Maignan et al.
patent: 4829080 (1989-05-01), Maignan et al.
patent: 4833240 (1989-05-01), Maignan et al.
patent: 4892940 (1990-01-01), Maignan et al.
patent: 5023363 (1991-06-01), Maignan et al.
Modulation of Cellular Interactions by Vitamin A and Derivatives (Retinoids), New York academy of Sciences, (1981) vol. 359, pp. 9-23.
Daub et al. Organic Prep. Proced. Int., 19(4-5), 269-76 (1987) * CAS Search Report*.
Graupner, G., et al., (1991) "6'-Substituted Naphthalene-2-Carboxylic Acid Analogs, A New Class Of Retinoic Acid Receptor Subtype-Specific Ligands", Biochem. Biophys. Res. Commun. 179(3):1554-1561.
Heyman, R. A., et al., (1992) "9-cis Retinoic Acid Is A High Affinity Ligand For The Retinoid X Receptor", Cell 68:397-406.
Pfahl et al., (1990) "Nuclear Retinoic Acid Receptors: Cloning, Analysis and Function", Methods In Enzymology 189:256-270.
Zhang, X., et al., (1992) "Homodimer Formation Of Retinoid X Receptor Induced By 9-cis Retinoic Acid", Nature 358:587-591.
Cameron James F.
Dawson Marcia L.
Hobbs Peter D.
Jong Ling
Lehmann Jurgen M.
Conrad Joseph M.
Dees Jos,e G.
La Jolla Cancer Research Foundation
SRI - International
LandOfFree
Bridged bicyclic aromatic compounds and their use in modulating does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Bridged bicyclic aromatic compounds and their use in modulating , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bridged bicyclic aromatic compounds and their use in modulating will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1222392