Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-05-24
1998-11-17
Lambkin, Deborah
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514440, 514448, 514433, 514432, 514456, 514356, 514337, 514336, 514569, 549454, 549398, 549 78, 549 71, 549 59, 549 39, 549 23, 546326, 5462797, 5462817, 562405, 562490, A61K 31335, A61K 3138, C07D31700, C07D33902
Patent
active
058377255
ABSTRACT:
Bridged bicyclic aromatic compounds are provided having the structure ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and n are as defined herein. The novel compounds are useful for modulating gene expression of retinoic acid receptors, vitamin D receptors and thyroid receptors. Pharmaceutical compositions and methods for modulating gene expression are provided as well.
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Cameron James F.
Dawson Marcia I.
Hobbs Peter D.
Jong Ling
Lehmann Jurgen M.
La Jolla Cancer Research Foundation
Lambkin Deborah
Reed Dianne E.
SRI - International
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