Bridged bicyclic amine derivatives useful as CCR-3 receptor...

Details Bridged bicyclic amine derivatives useful as CCR-3 receptor... Bridged bicyclic amine derivatives useful as CCR-3 receptor...

2006-07-25

2006-07-25

Tsang, Cecilia (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C546S094000, C548S428000

Reexamination Certificate

active

07081531

ABSTRACT:
Compounds having the formula (I),in-line-formulae description="In-line Formulae" end="lead"?Ar—(F)-(E)-(CR3R4)—(CHR5)m-(T)-(Q)-Ar1,in-line-formulae description="In-line Formulae" end="tail"?are useful as CCR-3 receptor antagonists, wherein T is a bridged heterocyclyl group having one N atom and a bridge of one to two bridgehead carbon atoms; Ar and Ar1are aryl or heteroaryl; F is alkylene, alkenylene, or a bond; E is —C(═O)N(R10)—, —SO2N(R10)—, —N(R11)C(═O)N(R10)—, —N(R11)SO2N(R10)—, —N(R11)C(═S)N(R10)—, —N(R11)C(═O)—, —N(R11)SO2—, —N(R12)C(═O)CH(R13)—, or CH(R13)C(═O)N(R12)—; Q is —C(═O)— or C1-2alkylene; and R3, R4, R5, R9, R10, R11, R12, and R13are defined as set forth in the specification.

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