Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Patent
1996-04-26
1998-06-23
Hollinden, Gary E.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
424 185, 424 165, 549346, 549350, 549 9, 546124, 546127, 546130, A61K 5104, C07D31300, C07D45102
Patent
active
057701806
ABSTRACT:
Disclosed are bridge-substituted analogs of tropanes and benztropines as well as methods for: imaging of cocaine receptors; treatment of cocaine abuse; and imaging and treatment of Parkinson's disease.
REFERENCES:
patent: 3040049 (1962-06-01), Harms
patent: 3351625 (1967-11-01), Harms
patent: 3452029 (1969-06-01), Childress et al.
patent: 3813404 (1974-05-01), Clarke et al.
patent: 4393069 (1983-07-01), Langbein et al.
patent: 5128118 (1992-07-01), Carroll et al.
Balster et al. "Potent Substituted-3.beta.-phenyltropane Analogs of Cocaine have Cocaine-like Discriminative Stimulus Effects" Drug and Alcohol Dependence, 29:145-151 (1991) Without Month.
Boja et al. "Isothiocyanate Derivatives of Cocaine: Irreversible Inhibition of Ligand Binding at the Dopamine Transporter" Molecular Pharmacology, 39:339-345 (1991) Without Month.
Boja et al. "New, Potent Cocaine Analogs: Ligand Binding and Transport Studies in Rat Striatum" European J. of Pharmacology, 184:329-332 (1990) Without Month. Huntington's Disease" J. Nuclear Med. Abs., 32:981 (1991) Without Month.
Canfield et al. "Autoradiographic Localization of Cocaine Binding Sites by 6:189-195 (1990) Without Month.
Carroll et al. "Probes for the Cocaine Receptor. Potentially Irreversible Ligands for the Dopamine Transporter" J. Med. Chem., 35:1813-1817 (1992) Without Month.
Carroll et al. "Cocaine Receptor: Biochemical Characterization and Structure-Activity Relationships of Cocaine Analogues at the Dopamine Transporter" J. Med. Chem., 35:969-981 (1992) Without Month.
Carroll et al. "Synthesis, Ligand Binding, QSAR, and CoMFA Study of 3.beta.-(p-Substituted phenyl)tropane-2.beta.-carboxylic Acid Methyl Esters" J. Med. Chem., 34:2719-2725 (1991) Without Month.
Carroll et al. "Synthesis and Ligand Binding of Cocaine Isomers at the Cocaine Receptor" J. Med. Chem., 34:883-886 (1991) Without Month.
Chen et al. "In Vivo Binding, Internalization, and Dopamine-Releasing Dopamine Transporter or Cocaine . . . " Soc. Neuro. Abs., 16:309.5 (1990) Without Month.
Clarke et at. "(2-exo-3-endo)-2-Aryltropane-3-carboxylic Esters, a New Class of Narcotic Antagonists" J. Med. Chem., 21:1235-1242 (1978) Without Month.
Clarke et al. "Compounds Affecting the Central Nervous System. 4. 3.beta.-Phenyltropane-2-carboxylic Esters and Analogs" J. Med. Chem., 16:1260-1267 (1973) Without Month.
Cline et al. "Behavior Effects of Novel Cocaine Analogs: A Comparison with in Vivo Receptor Binding Potency" J. Pharm. & Exp. Therapeutics, 260:1174-1179 (1992) Without Month.
Daum et al. "Compounds Affecting the Central Nervous System. 3..sup.1 3.beta.-Phenyltropan-2-ols" J. Med. Chem., 16:667-670 (1973) Without Month. and Glucose Utilization in a Primate Model of Huntington's Disease" J. Nuclear Med. Abs., 32:552 (1991) Without Month.
Elmaleh et al. "Preparation and In Vivo Imaging of Brain" J. Nuclear Med. Abs., 32:1009 (1991) Without Month.
Elmaleh et al. "PET Imaging Probes for the Cocaine Receptors: A Validation Study in a Nonhuman Primate Model" J. Nuclear Med. Abs., 33:946 (1992) Without Month.
Goodman et al. "Radioiodinated 2.beta.-Carbomethoxy-3.beta.-(4-Chlorophenyl)-8-(3E-and 3Z-Iodopropen-2-YL)Nortropanes: Synthesis of Potential Radioligands for Mapping Cocaine Receptor . . . " J. Nuclear Med. Abs., 33:890 (1992) Without Month. Primate Model of Parkinsonism" Clin. Neurosci. and Neuropath., 3:265-268 (1992) Without Month.
Hillier "WIN-35,428" Drugs of the Future, 5:459-460 (1980) Without Month.
Horn "Dopamine Uptake: A Review of Progress in the Last Decade" Progress in Neurobiology, 34:387-400 (1990) Without Month.
Innis et al. "Single Photon Emission Computed Tomography Imaging of Pharmacol., 200:369-370 (1991) Without Month.
Kaufman et al. "Severe Depletion of Cocaine Recognition Sites Associated With the Dopamine Transporter in Parkinson's-Diseased Striatum" Synapse, 9:43-49 (1991) Without Month.
Kitayama et al. "Dopamine Transporter Site-Directed Mutations Differentially Alter Substrate Transport and Cocaine Binding" Proc. Natl. Acad. Sci., 89:7782-7785 (1992) Without Month.
Kline, Jr. et al. "Synthesis of 3-Arlecgonine Analogues as Inhibitors of Cocaine Binding and Dopamine Uptake" J. Med. Chem., 33:2024-2027 (1990) Without Month.
Leete "2-Carbomethoxy-3-tropinone: An Advanced Intermediate in the Biosynthesis of Cocaine" J. Amer. Chem. Soc., 105:6727-6728 (1983) Without Month.
Madras ".sup.11 C-WIN 35,428 for Detecting Dopamine Depletion in Mild Parkinson's Disease" Annals of Neuro., 35:376-377 (1994) Without Month.
Madras et at. "N-Modified Fluorophenyltropane Analogs of Cocaine With High Affinity for Cocaine Receptors" Pharmacol. Biochem. & Behav., 35:949-953 (1990) Without Month. Receptors" Soc. for Neurosci. Abstracts, 15:803 (1989) Without Month.
Madras et al. "Cocaine Receptors Labeled by Pharmacology, 36:518-524 (1989) Without Month. FASEB J. Abstracts, 2:A1137 (1988) Without Month.
Meltzer et al. "Substituted 3-Phenyltropane Analogs of Cocaine: Synthesis, Inhibition of Binding at Cocaine Recognition Sites, and Positron Emission Tomography Imaging" J. Med. Chem., 36:855-862 (1993) Without Month.
Milius et al. "Synthesis and Receptor Binding of N-Substituted Tropane Derivatives. High-Affinity Ligands for the Cocaine Receptor" J. Med. Chem., 34:1728-1731 (1991) Without Month. Amer. Chem. Soc. Abstract, 199:1 (1990) Without Month. tropane: High-Affinity SPECT Radiotracer of Monoamine Reuptake Sites in Brain" J. Med. Chem., 34:3144-3146 (1991) Without Month.
Patet et al. "A Cocaine Analog and a GBR Analog Label the Same Protein in Rat Striatal Membranes" Brain Res., 576:173-174 (1992) Without Month.
Reith et al. "Radiolabeling of Dopamine Uptake Sites in Mouse Striatum: Comparison of Binding Sites for Cocaine, Mazindol, and GBR 12935" Arch. of Pharmacol., 345:309-318 (1992) Without Month.
Ritz et al. "Cocaine Inhibition of Ligand Binding at Dopamine, Norepinephrine and Serotonin Transporters: A Structure-Activity Study" Life Sciences, 46:635-645 (1990) w/o Month.
Rubenstein "III Imaging With Photons" Scientific American, 1/88:1-14 (1988) w/o Month.
Scheffel et al. "In Vivo Labeling of Cocaine Binding Sites on Dopamine Therapeutics, 257:954-958 (1991) w/o Month.
Scheffel et al. Cocaine Receptors: In Vivo Labeling With .sup.3 H-(-)Cocaine, .sup.3 H-WIN 35,065-2, and .sup.3 H-WIN 35,428 Synapse, 4:390-392 (1989) w/o Month.
Spealman et al. "Self-Administration of the High Affinity Cocaine Analog 2.beta.-Carbomethoxy-3.beta. (4-Fluorophenyl) Tropane" Pharmacol. Biochem. & Behavior, 39:1011-1013 (1991) w/o Month.
Zakusov et al. "Pharmacology of New Tropan Derivatives" Pharmac. Ther., 32:327-337 (1987) w/o Month.
Isacson "Clinical and Preclinical PET Correlates of Parkinsonism with .sup.11 C-WIN 35,428" Annals of Neuro., 35:377-378 (1994) w/o Month.
Meyer et al. "Intravenously Administered Dopamine Transporter Site Radioligand is Not Significantly Retained in Mouse Substantia Nigra or Other Sites Outside of . . . " Annals of Neurology, 35:378-379 (1994) w/o Month.
Bergman et al., J. Pharmacol. Exp. Ther., 251:150-155 (1989) w/o Month.
Calligaro and Eldefrawi, J. Pharmacol. Exp. Ther., 243:61-68 (1987) w/o Month.
Calligaro and Eldefrawi, Membrane Biochem., 7:87-106 (1988) w/o Month.
Javaid et al., Science, 202:227-228 (1978) w/o Month.
Madras et al., FASEB J., 2:A1137 (1988) w/o Month.
Madras et al., ASP/ASPET Abstr., A197 (1988) w/o Month.
Madras et al., J. Pharmacol. Exp. Ther., 251:131-141 (1989) w/o Month.
Misra et al., Drug Alcohol Depend., 2:261-272 (1977) w/o Month.
Reith et al., Biochem. Pharmacol., 35:1123-1129 (1986) w/o Month.
Schoemaker et al., Naunyn-Schmiedeberg's Arch. Pharacol., 329:227-235 (1985) w/o Month.
Spealman et al., J. Pharmacol. Exp. Ther., 251:142-149 (1989) w/o Month.
Spealman et al., J. Pharmacol. Exp. Ther., 258:945-953 (1991) w/o Month.
Van Dyke et al., Science, 191:859-861 (1976) w/o Month.
Reith et al., Biochem. Pharmacol. 35:1123-1129 (1986) w/o Month.
Calligaro and Eldefrawi, J. Pharmacol. Exp. Ther. 243:61-68 (1987) w/o Month.
Calligaro and Eldefrawi, Membrane Biochem. 7:87-106 (1988) w/o Month.
Schoemaker et al., Naunyn-Sch
Madras Bertha K.
Meltzer Peter
Hartley Michael G.
Hollinden Gary E.
Organix Inc.
President and Fellows of Harvard College
LandOfFree
Bridge-substituted tropanes for methods of imaging and therapy does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Bridge-substituted tropanes for methods of imaging and therapy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bridge-substituted tropanes for methods of imaging and therapy will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1392405