Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-06-29
1997-12-09
Grumbling, Matthew V.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549270, 548525, 548256, 5482664, 5483644, 548240, 548239, 548238, 5483114, 548146, 548214, 548131, 548125, 544376, 544147, 544 2, 544 66, 544215, 540596, 540553, 540544, 514422, 514253, 5142335, 514359, 514383, 514212, 514218, 514211, 514403, 514378, 514374, 514252, 514241, 5142225, 5142292, 514397, 514365, 514372, 514364, C07D31300, C07D40512, C07D41312, A61K 31365
Patent
active
056961545
ABSTRACT:
Provided are brefeldin A derivatives of the formula: ##STR1## wherein one of R.sub.1 and R.sub.2 is H and the other of R.sub.1 and R.sub.2 is a substituent group having 1 to 12 carbon atoms containing a basic nitrogen atom or a quaternary ammonium group, or a salt thereof. These derivatives exhibit good antitumor activity, and are administrable to human patients without the problems associated with brefeldin A.
REFERENCES:
Haerri, E. et al. Chemical Abstract 59, 5726h (1963).
Banerjee, P.K. et al. Design of Prodrugs, Bundgaard, H. ed. (Elsevier Science, Amsterdam), pp. 93-96 (1985).
Kovach, I.M. et al. J. Pharm. Sci. 64, 1070-1071 (1975).
Connors, T.A. Xenobiotica 16, 975-988 (1986).
Kane, Jr. Charles Theodore
Malspeis Louis
Supko Jeffrey G.
Vishnuvajjala B. Rao
Grumbling Matthew V.
Starks Associates, Inc.
The United States of America as represented by the Department of
Wong King Lit
LandOfFree
Brefeldin A derivatives and their utility in the treatment of ca does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Brefeldin A derivatives and their utility in the treatment of ca, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Brefeldin A derivatives and their utility in the treatment of ca will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1608147