Surgery – Miscellaneous – Methods
Patent
1997-02-26
2000-05-30
Weiss, John G.
Surgery
Miscellaneous
Methods
600532, 422 84, 73 233, A61B 1900, C07C 202
Patent
active
060679891
ABSTRACT:
A breath test for diagnosing the presence of Helicobacter pylori in a subject is described. The method of diagnosing Helicobacter pylori is performed as follows. First, a safe and effective amount of urea, preferably appropriately labelled, is administered to the subject. Second, a plurality of the exhaled breaths of the subject is analyzed to detect the concentration of a cleavage product or products, produced when urease cleaves the substrate. The measured concentrations are then fitted to a curve, and the derivative is then calculated, to indicate the presence or absence of Helicobacter pylori infection in the subject.
REFERENCES:
patent: 4440177 (1984-04-01), Anderson et al.
patent: 4444201 (1984-04-01), Itoh
patent: 4830010 (1989-05-01), Marshall
patent: 4947861 (1990-08-01), Hamilton
patent: 5042501 (1991-08-01), Kenny et al.
patent: 5046017 (1991-09-01), Flewelling et al.
patent: 5063275 (1991-11-01), Rosenfeld et al.
patent: 5231591 (1993-07-01), Flewelling et al.
patent: 5309921 (1994-05-01), Kisner et al.
patent: 5363857 (1994-11-01), Howard
patent: 5510269 (1996-04-01), Black et al.
patent: 5543521 (1996-08-01), Chan et al.
patent: 5570697 (1996-11-01), Walker et al.
patent: 5640014 (1997-06-01), Sauke et al.
patent: 5705735 (1998-01-01), Acorn
patent: 5719052 (1998-02-01), Ito et al.
patent: 5848975 (1998-12-01), Phillips
patent: 5944670 (1999-08-01), Katzman
patent: 5957858 (1999-09-01), Micheels et al.
patent: 5962335 (1999-10-01), Katzman
patent: 5964712 (1999-10-01), Kubo et al.
Bloch, K., The Journal of Biological Chemistry, "The Metabolism of I(+)-Arginine in the Rat", vol. 165, No. 2, pp. 469-484, 1946.
Caldwell, S.H., et al. Clinical Research, "How Common is Campylobacter Pylori in Persons without Dyspepsia?", vol. 37, No. 1, 1989.
Caldwell, S.H., et al. The American Journal of Medicine, "Possible Role of Campylobacter Pylori in Idiopathic Hyperammonemia", vol. 87, pp. 249-250, 1989.
DeCross, A.J., et al. Journal of Clinical Microbiology, "Metronidazole Susceptibility Testing for Helicobacter pylori Comparison of Disk, Broth, and Agar Dilution Methods and Their Clinical Relevance", vol. 31, No. 8, pp. 1971-1974, 1993.
Dye, K.R., et al. Digestive Diseases and Sciences, "Ultrastructure of Another Spiral Organism Associated with Human Gastritis", vol. 34, No. 11, pp. 1787-1791, 1989.
Evans, D.J., Gastroenterology, "A Sensitive and Specific Serologic Test for Detection of Campylobacter pylori Infection", vol. 96, No. 4, pp. 1004-1008, 1989.
Frierson, H.F . Jr., et al. Laboratory Investigation, "A Spiral Bacterium Distinct from Campylobacter Pylori that Causes Gastritis in Humans", vol. 60, No. 1, 1989.
Godle, H., et al. Nuclear Science Abstracts, vol. 4, No. 18, p. 806, 1950.
Graham, D.Y., et al. The American Journal of Gastroenterology, "Campylobacter pyloridis Gastritis: The Past, the Present, and Speculations about the Future", vol. 82, No. 4, pp. 283-286, 1987.
Graham, D.Y., et al. The Lancet, "Campylobacter Pylori Detected Noninvasively by the [.sup.13 C]-Urea Breath Test", vol. I, pp. 1174-1177, 1987.
Graham, D.Y., et al. Scandinavian Journal of Gastroenterology, "Epidemiology of Campylobacter pylori Infection: Ethnic Considerations", pp. 9-13, 1988.
Graham, D.Y., et al. The Journal of Infectious Diseases, "Effect of Age on the Frequency of Active Campylobacter pylori Infection Diagnosed by the .sup.13 C-Urea Breath Test in Normal Subjects and Patients with Peptic Ulcer Disease", vol. 157, No. 4, pp. 777-780, 1988.
Graham, D.Y., et al. The American Journal of Gastroenterology, "In Vivo Susceptibility of Campylobacter pylori", vol. 84, No. 3, pp. 233-238, 1989.
Kerr, D., et al. The Lancet, "Adrenaline Response to Hypoglycemia and Insulin Species", vol. I, p. 836, 1989.
Klein, P.D., Stable Isotopes in Nutrition Research, "Clinical Applications of .sup.13 CO.sub.2 Measurements" pp. 2698-2701, 1982.
Klein, P.D., The Lancet, "Water Source as Risk Factor for Helicobacter pylori Infection in Peruvian Children" vol. 337, No. 8756, pp. 1503-1506, 1991.
Klein, P.D., et al. The American Journal of Gastroenterology, "Noninvasive Detection of Helicobacter pylori Infection in Clinical Practice: The .sup.13 C Urea Breath Test", vol. 91, No. 4, pp. 690-694, 1996.
Kornberg, H.L., Davies, R.E., II.sup.e Congres International de Biochimie, "The Metabolism of Urea in the Cat", 1959.
Langham, W.H., The Journal of Biological Chemistry, "Studies on the Metabolism of Radioactive Nicotinic Acid and Nicotinamide in Mice", vol. 176, No. 1, pp. 249-257, 1948.
Leifer, E., et al. Science, "Metabolism of C.sup.14 -labeled Urea", vol. 108, p. 748, 1948.
Marshall, B.J., et al. The Lancet, "Unidentified Curved Bacilli in the Stomach of Patients with Gastritis and Peptic Ulceration", vol. I, pp. 1311-1315, 1984.
Marshall, B.J., et al. The Medical Journal of Australia, "Pyloric Campylobacter Infection and Gastroduodenal Disease", vol. 142, pp. 439-444, 1985.
Marshall, B.J., The Journal of Infectious Diseases, "Campylobacter pyloridis and Gastritis", vol. 153, No. 4, pp. 650-657, 1986.
Marshall, B.J., et al. The Journal of Nuclear Medicine, "Sensitive, Specificity and Reproducibility of the C-14 Urea Breath Test: Evaluation in Patients with C. pylori", vol. 29, No. 5, p. 790, 1988.
Marshall, B.J., The American Journal of Gastroenterology, "Should We Now, Routinely, Be Examining Gastric Biopsies for Campylobacter pylori?", vol. 83, No. 5, pp. 479-481, 1988.
Marshall, B.J., Gastroenterologie Clinique et Biologique, "Experimental models in vivo for Campylobacter pylori", vol. 13, 1989.
Marshall, B.J., et al. Gastroenterology, "Microdose, Capsule-Bases, 14C-Urea Breath Test For H. Pylori", vol. 96, No. 5, p. 321, 1989.
Marshall, B.J., et al. Gastroenterology, "Urea Protect Helicobacter (Campylobacter) pylori from the Bactericidal Effect of Acid", vol. 99, No. 3, 1990.
Marshall, B.J., et al. Gastroenterology, "Gastric Suction Biopsy--A Non-endoscopic Method to Diabnose Helicobacter Pylori", vol. 98, No. 5, p. 83, 1990.
Marshall., B.J., The American Journal of Gastroenterology, "Helicobacter pylori", vol. 89, No. 8, pp. 116-128, 1994.
Opekun, A.R., et al. Digestive Diseases and Sciences, "[.sup.13 C] Aminopyrine Breath Test Detects Altered Liver Metabolism Caused by Low-Dose Oral Contraceptives", vol. 40, No. 11, pp. 2417-2422, 1995.
Warren, J.R., The Lancet, "Unidentified Curved Bacilli on Gastric Epithelium in Active Chronic Gastritis", pp. 1273-1275, 1983.
Watkins, J.B., The Journal of Laboratory and Clinical Medicine, ".sup.13 C-trioctanoin: a Nonradioactive Breath Test to Detect Fat Malabsorption" vol. 90, No. 3, pp. 422-430, 1977.
Marshall, B.J., The American Journal of Gastroenterology, "Rapid Urease Test in the Management of Campylobacter pyloridis-Associated Gastritis", vol. 82, pp. 200-210, 1987.
Marshall, B. J., Gastroenterology, vol. 92, p. 1517, 1987 Marshall, B.J., Gastroenterology, "Fifteen Minute Urea-C14 Breath Test for the Diagnosis of Campylobacter Associated Gastritis", vol. 92, p. 1517, 1987.
Marshall, B.J., et al., The Journal Of Nuclear Medicine, "Carbon-14 Urea Breath Test for the Diagnosis of Campylobacter pylori Associated Gastritis", vol. 29, pp. 11-16, 1988.
Marshall, B.J., Clinical Research, "A Rapid 14C-Urea Breath Test for the Diagnosis of C. pylori Associated Gastritis", vol. 36, p. 14A, 1988.
Marshall, B.J., The American Journal of Gastroenterology, "Is CLOtest Alone Adequate to Diagnose Campylobacter-pylori?", vol. 83, No. 9 p. A284, 1988.
Dye, K.R., et al., Gastroenterology, "Comparison of Carbon-14 Urea Breath Test Microbiology and Histology for the Diagnosis of Campylobacter-pylori", vol. 83, No. 9 p. 1032. 1988.
Marshall, B.J., Jama-Journal Of The American Medical Association, "Campylobacter-pylori--Diagnosis and Treatment", p. 2916, 1988.
Marshall, B.J., Scandinavian Journal Of Gastroenterology, "The Campylobacter pylori Story", vol. 23, pp. 58-66, 1988.
Caldwell, S.H., et al., Drug Therapy, "Campylobacter pylori and Peptic Disease," pp. 92-106, 1989.
Marshall, B. J., Supplement To Gastroenterology, "Simplifying the Urea Breath Test for C.pylori", vol. 96, p
Ingerman Jeffrey H.
Oridion Medical Ltd.
Weiss Joel
Weiss John G.
Weiss, Jr. Joseph F.
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