Breath test for detection of drug metabolism

Details Breath test for detection of drug metabolism Breath test for detection of drug metabolism

1997-01-03

1999-10-05

Wallenhorst, Maureen M.

Chemistry: analytical and immunological testing

Including sample preparation

Gaseous sample or with change of physical state

436 56, 436133, 436173, 436900, 422 83, 422 84, 73 233, G01N 122

Patent

active

059623357

ABSTRACT:
A breath test for determining the rate of metabolism of a drug is described. First, a safe and effective amount of the drug, preferably appropriately labelled and most preferably isotopically-labelled, is administered to a subject. After a suitable time period, the exhaled breath of the subject is analyzed to determine the concentration of a metabolite. The concentration of the metabolite is then used to determine the rate of metabolism of the drug. A breath test kit is also described. Such a breath test kit would include an item or items necessary for performing at least one of the methods of determining the rate of metabolism of a drug in a subject. For example, such a breath test kit could include an isotopically-labelled drug to be administered to the subject.

REFERENCES:
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patent: 4298347 (1981-11-01), Walsh
patent: 4676974 (1987-06-01), Hofmann et al.
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patent: 5063275 (1991-11-01), Rosenfeld et al.
patent: 5100779 (1992-03-01), Watkins
patent: 5317156 (1994-05-01), Cooper et al.
patent: 5386832 (1995-02-01), Wagner et al.

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