Breath test

Details Breath test Breath test

2002-12-09

2008-03-04

Nasser, Robert L. (Department: 3735)

Surgery

Diagnostic testing

Respiratory

C073S023300, C422S084000

Reexamination Certificate

active

07338454

ABSTRACT:
A method of assessing the state of the lining of the small intestine in a mammal or human injesting a suitable labelled test substrate which requires conversion by a brush border enzyme for transport across the small intestinal lining. Suitable substrates include sucrose and maltose. The transport of these can very conveniently be measured by assessing the amount of label present in carbon dioxide expelled in the breath after a period of time. It has been shown that this method has application to assessing damage cause by chemotherapeutic induced mucositis as well as gastroenteritis with an infectious cause.

REFERENCES:
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patent: 6186958 (2001-02-01), Katzman et al.
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Sasaki, et al., “intestine: Physiological Function Test and Inflammation—Evaluation of Intestinal Mucosal Function by Measuring Expired 14CO2 After oral Administration of 14C-Putrescine”, Journal of Gastroenterology and Hepatology, 16:986-990.

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