Breast cancer resistance protein (BCRP) and the DNA which...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

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C530S388100, C530S388800, C530S388850, C435S007100

Reexamination Certificate

active

07541437

ABSTRACT:
The Breast Cancer Resistance Protein is described, as well as the cDNA encoding said protein. This protein has been found to confer resistance to cancer chemotherapeutic drugs.

REFERENCES:
patent: 5585479 (1996-12-01), Hoke
patent: 6060248 (2000-05-01), Lane
patent: 2003/0232362 (2003-12-01), Komatani et al.
patent: WO94/10303 (1994-05-01), None
patent: WO 98/55614 (1998-12-01), None
patent: WO99/58675 (1999-11-01), None
patent: WO00/18912 (2000-04-01), None
patent: WO00/36101 (2000-06-01), None
Bowie et al (Science, 1990, 257:1306-1310).
Burgess et al (J. Cell Bio., 1990, 111:2129-2138).
Lazar et al (Molecular and Cellular Biology, 1988, 8:1247-1252).
Filipits et al (Clinical Cancer Research, 2996, 3:1231-1237).
Dexter et al (Proc. AACR, 1996, 37:A2138).
Harlow et al (Antibodies:A Laboraty Manual, COld Spring Harbor Laboratory Press, 1988, p. 142).
Nakagawa et al (Cancer Research 52, 1992, 6175-6181).
Purnelle et al (GenBank, Sequence Database Accession P25371), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, publicly available 1 May 1.
Kirby et al (GenBank, Sequence Database Accession Q94960), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, publicly available Feb. 1, 1997.
Roitt et al (Immunology, 1993, Mosby, St. Louis, p. 6.4-6.5).
Herbert et al (The Dictionary of Immunology, Academic Press, 4th Edition, London, 1985, pges 58-59).
Oches, Autoantibodies in Breast Cancer, electronic reference at http://www.cbcrp.org/research/PageGrant.asp?grant—id=198.
Gibbons et al Mol Biol. Cell 5:57-70(1994).
Allikmets et al (Cancer Research, Dec. 1, 1998, 58:53337-53339, IDS).
Campbell, A. (Laboratory Techniques in Biochemistry And Molecular Biology, vol. 13, Chapter 1, pp. 1-33, 1984).
U.S. Appl. No. 60/073,763; p. 3 “Summary of the Invention,” p. 6 “Detailed Description of the Invention,” p. 1-2 “Claims,” and Figure 2A, one page.
GenBank Acession No. AAC97367 (GI:4038352), p. 1-3, IDS.
“Sequence alignment of SEQ ID No. 1 and AAC97367” p. 1-2, IDS.
Hillier L., et al., “Generation and Analysis of 280,000 Humana Expressed Sequence Tags,” Genome Research, 1996, vol. 6(9):807-828.
Jaroszewski, et al., “Concerning Antisense Inhibition of the Multiple Drug Resistance Gene,” Cancer Communications, 1990, vol. 2(8):287-294.
Yang, et al., “Cloning and Characterization of Breast Cancer Resistance Protein (BCRP), A Novel ATP-Binding Cassette (ABC) Transporter That May Contribute to the Multi-drug Resistance Phenotype of MCF-7/ADRVP Breast Cancer Cells,” Proceedings of the 89th Annual Meeting of the American Association for Cancer Research, 1998, vol. 39:657 (abstract).
Amplification of 4q21-q22 and the MXR Gene in Independently Derived Mitoxantrone-Resistant Cell lines, Turid Knusten, V. Koneti Rao, Thomas Ried, Lyn Mickley, Eramus Schneider, Keisuke Miyake, B. Michael Ghadimi, Hesed Padilla-Nash, Svetlana Pack, Lee Greeneberger, Kenneth Cowan, Michael Dean, Tito Fojo, and Susan Bates, Genes, Chromosomes and Cancer, vol. 27 pp. 110-116.
Atypical Multidrug Resistance: Breast Cancer Resistance Protein Messenger RNA Expression in Mitaxantrone-Selected Cell Lines. Douglas D. Ross, Weidong Yang, Lynne V. Abruzzo, William S. Dalton, Erasmus Schneider, Hermann Lage, Munfred Dietel, Lee Greenberger, Susan P.C. Cole, L. Austin Doyle. JNCI, vol. 91, No. 5, Jan. 28, 1999, pp. 1-11.
Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the Expressed Sequence Tags database. Rando Allikmets, Bernard Gerrard, Amy Hutchinson and Michael Dean, Human Molecular Genetics, 1996, vol. 5, No. 1, pp. 1649-1655.
Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line. S.P.C. Cole, G. Bhardwaj, J.H. Gerlach, J.E. Mackie, C.E. Grant, K.C. Almquist, A.J. Stewart, E.U. Kurz, A.M.V. Duncan, R.G. Deeley, vol. 258, Dec. 4, 1992, pp. 1650-1654.
Reduced Intracellular Drug Accumulation in the Absence of P-Glycorprotein (mdr1) Overexpression in Mitoxantrone-resistance Human MCF-7 Breast Cancer Cells, Masayuki Nakagawa, Erasmus Schneider, Katharine H. Dixon, Julie Horton, Kristin Kelly, Charles Morrow, Kenneth H. Cowan, Cancer Research, vol. 52, 6175-6181, Nov. 15, 1992.
Cross-Resistance to Camptothecin Analogues in a Mitoxantrone-resistance Human Breast Carcinoma Cell Line Is Not Due to DNA Topoisomerase I Alterations, Chih-Hsin J. Yang, Julie K. Horton, Kenneth H. Cowan and Erasmus Schneider, Cancer Research vol. 55, pp. 4004-4009, Sep. 15, 1995.
Characterization of Adriamycin-resistant Human Breast Cancer Cells Which Display Overexpression of a Novel Resistance-related Membrane Protein, Yi-Nan Chen, Lyn A. Mickley, Arnold M. Schwartz, Edward M. Action, Jaulang Hwang, and Antonio T. Fojo, The Journal of Biological Chemistry, vol. 265, No. 17, pp. 10073-10080, Jun. 15, 1999.
Membrane Vesicle Formation Due Aquired Mitoxantrone Resistance in Human Gastric Carcinoma Cell Line EPG85-257, Manfred Dietel, Hartmut Arps, Hermann Lage and Axel Niendorf, Cancer Research, vol. 50, 6100-6106, Sep. 15, 1990.
Different Mechanisms of Decreased Drug Accumulation in Doxorubicin and mitoxantrone resistance variants of the MCF7 Human Breast Cancer Cell line, C.W. Taylor, W.S. Dalton, P.R. Parrish, M.C. Gleason, W.T. Bellamy, F.H. Thompson, D.J. Roe and J.M. Trent, J. Cancer vol. 63, pp. 923-929, (1991).
Fumitremorigin C Reverse Multidrug Resistance in Cells Transfected with the Breast Cancer Resistance Protein, Sridhar K. Radindran, Douglas D. Ross, L. Austin Doyle, Weidong Yang, and Lee M. Greenberger, Cancer Research, vol. 60, pp. 47-50, Jan. 1, 2000.
Analysis of MRP mRNA in Mitoxantrone-Selected, Multidrug-Resistant Human Tumor Cells, Bernard W. Futscher, Mohammad R. Abbaszadegan, Federick Domann, and William S. Dalton, Biochemical Pharmacology, vol. 47, No. 9 pp. 1601-1606, 1994.
Cytogenic and Phenotypic Analysis of a Human Colon Carcinoma Cell Line Resistant To Mitoxantrone, William S. Dalton, Anne E. Cress, David S. Alberts and Jeffrey M. Trent, Cancer Research, vol. 48, 1882-1888, Apr. 1, 1988.
Reduced Drug Accumulation and Multidrug Resistance in Human Breast Cancer Cells without Associated P-Glycoprotein or MPR Overexpression, Jong Seok Lee, Stefania Scala, Yoshihito Matsumoto, Bruce Dickstein, Rob Robey, Zhirong Zhan, Guillermo Altenberg, and Susan E. Bates, Journal of Cellular Biochemistry vol. 65, pp. 513-526, 1997.
Decreased Drug Accumulation in a Mitoxantrone-Resistance Gastric Carcinoma Cell Line in the Absence of P-Glycorprotein, Udo Kellner, Lesley Hutchinson, Andre Seidel, Hermann Lage, Mary K. Danks, Manfred Dietel and Scott H., Kaufmann, Int. J. Cancer vol. 71, pp. 817-824, 1997.
Reduced Cellular Accumulation of Topotecan: a novel Mechanism of Resistance in a Human Ovarian Cancer Cell Line, J. Ma, M. Maliepaard, K. Nooter, WJ. Loos, H.J. Kolker, J. Verweij, G. Stoter and JHM Schellens, British Journal of Cancer, vol. 77(10), pp. 1645-1652, 1998.
Reversal of a Novel Mulitdrug Resistance Mechanism in Human Colon Carcinoma Cells By Fumitremorgin C, Sridhar K. Rabindran, Haiyan He, Maya Singh, Eileen Brown, Karen I. Collins, Tami Annable, and Lee M. Greenberger, Cancer Research vol. 58, pp. 5850-5858, Dec. 15, 1998.
Overexpression of the BCRP/MXR/ABCP Gene in a Toptecan-selected Ovarian Tumor Cell Line, Marc Maliepaards, Margot A. Van Gastelen, Laurina A. de Jong, Dick Pluim, Robert C. A. M. van Waardenburg, Marjan C. Ruevekamp-Helmers, Ben G. J. Floot, and Jan H. M. Schellens, Cancer Research vol. 59, pp. 4559-4563, Sep. 15, 1999.
Expression of the Novel Mitoxantrone Resistance Associated Gene MXR7 in Colorectal Malignancies, H. Lage, M. Dietel, G. Froschle, and Reymann, Internation Jmournal fo Clinical Pharmacology and Therapeutics, vol. 36, No. 1, p. 58-60, 1998.
The Mouse Bcrp1/Mxr/Abcp Gene: Amplification and Overexpression in Cell Lines Selected Resistance Toptecan, Mitoxantrone, or Doxorubicin, John D. Allen, Remco F. Brinkhuis, Jan Wijnholds and Alfred H. Sch

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