Breast cancer prognostics

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C435S004000, C435S007100, C435S007210, C435S007230, C436S064000, C436S174000, C536S001001, C536S001110, C536S018700, C536S022100, C536S023100, C536S023500

Reexamination Certificate

active

10422522

ABSTRACT:
A method of providing a prognosis of breast cancer is conducted by analyzing the expression of a group of genes. Gene expresson profiles in a variety of medium such as microarrays are included as are kits that contain them.

REFERENCES:
patent: WO 99/33982 (1999-07-01), None
patent: WO 02/10436 (2002-02-01), None
patent: WO 02/059271 (2002-08-01), None
patent: WO 02/068579 (2002-09-01), None
patent: WO 2004/065545 (2004-08-01), None
patent: WO 2004/079014 (2004-09-01), None
Van De, Marc J. et al., “A Gene-Expression Signature as a Predictor of Survival in Breast Cancer”, The New England Journal of Medicine Massachusetts Medical Society, Boston, MA, U.S., vol. 347, No. 25, Dec. 2002, pp. 1999-2009, Vliver.
Bertucci, Francois et al., “Prognosis of Breast Cancer and Gene Expression Profiling Using DNA Arrays”, Annual New York Academby of Science, New York, NY, U.S., vol. 975, Dec. 2002, pp. 217-231.
Bertucci, Francois et al., “Gene Expression Profiles of Poor-Prognosis Primary Breast Cancer Correlate with Survival”, Human Molecular Genetics, Oxford University Press, Surrey, Great Brittan, vol. 11, No. 8, Apr. 2002, pp. 863-872.
Bertucci, Francois et al., “Gene Expression Profiling of Primary Breast Carcinomas Using Arrays fo Candidate Genes”, Human Molecular Genetics, vol. 9, No. 20, Dec. 2000, pp. 2981-2991.
Sorlie, Therese et al., “Gene Expression Patters of Breast Carcinomas distinguish Tumor Subclasses with Clinical Implications”, Proceedings of the National Academy of Sciences fo USA, National Academy of Science, Washington, U.S., vol. 98, No. 19, Sep. 2001.
Martin, Katherine J., “Linking Gene Expression Patterns to Therapeutic Groups in Breast Cancer”, Cancer Research, American Association for Cancer Research, Baltimore, MD, U.S.
Perou, Charles M. et al., “Molecular Portraits of Human Breast Tumours”, Nature, MacMillan Journals Ltd., London, Great Brittan, vol. 406, No. 6797, Aug. 2000, pp. 747-752.
Sofia K. et al.; “Gene expression profiling to predict outcome in breast cancer; the influence of sample selection”, Breast Cancer Res 2003, 5:23-26 (DOI 10.1186/bcr548) (Print ISSN 1465-5411; Online ISSN 1465-542CX) Received: Aug. 7, 2002 Accepted: Sep. 20, 2002 Published Oct. 11, 2002, Gurvberger.
Partial European Search Report, dated Dec. 27, 2004, for European Appln. No. EP 0425 2389.
Martin, Katherine J., “Linking Gene Expression Patterns to Therapeutic Groups in Breast Cancer”, Cancer Research, American Association for Cancer Research, Baltimore, MD, U.S, Apr. 15, 2000.
Dai, Hongyue, et. al, “A Cell Proliferation Signature Is a Marker of Extremely Poor Outcome in a Subpopulation of Breast,” Cancer Res 2005; 65: (10). May 15, 2005.

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