BRC/ABL transgenic animals as models for Philadelphia chromosome

Details BRC/ABL transgenic animals as models for Philadelphia chromosome BRC/ABL transgenic animals as models for Philadelphia chromosome

1993-01-14

1996-02-13

Chambers, Jasemine C.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

800DIG1, 4351723, 4352402, 4353201, 4353171, 935 70, 935111, C12N 1500

Patent

active

054912830

ABSTRACT:
The present invention relates to non-human transgenic animals which contain a transgene comprising a BCR/ABL gene fusion and which develop leukemia. In a preferred embodiment of the present invention, the transgenic animals exhibit a rapid induction of acute leukemia.
The present invention offers the advantage of providing, for the first time, a non-human transgenic animal model system which carries the BCR/ABL gene fusion characteristic of the Philadelphia chromosome and which develops leukemia in a manner directly analogous to the clinical progression of chronic myelogenous leukemia (CML) and/or acute lymphoblastic leukemia (ALL) in humans. This model system for human leukemia may be valuable in obtaining a better understanding of CML and ALL and in developing effective therapeutic regimens.

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