Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills
Patent
1995-09-27
1997-11-11
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Tablets, lozenges, or pills
424489, A61K 920, A61K 914
Patent
active
056861087
ABSTRACT:
A brassica vegetable tablet contains at least 50 ug of sulforaphane and a maximum of 50 ug of sulforaphane-nitrile. A process for producing a brassica vegetable product includes inactivating endogenous myrosinase enzyme in a brassica vegetable and thereafter blending the vegetable with exogenous myrosinase enzyme. The preferred process may include steam blanching as the method of inactivating the endogenous myrosinase enzyme. The preferred process may also include horseradish root as the source of exogenous myrosinase enzyme.
REFERENCES:
patent: 98875 (1870-01-01), Mays et al.
patent: 4083836 (1978-04-01), Anjou et al.
patent: 4244973 (1981-01-01), van Megen
patent: 4338350 (1982-07-01), Chen et al.
patent: 4496598 (1985-01-01), Sakai et al.
patent: 5248504 (1993-09-01), Friedman
patent: 5411986 (1995-05-01), Cho et al.
Glucosinolates and Derived Products in Cruciferous Vegetables. Identification of Organic Nitriles from Cabbage, J. Agric. Food Chem., vol. 25, No. 1, 1977.
Glucosinolate Products in Commercial Sauerkraut, J. Agric. Food Chem., 1980, 28, 809-811.
Production of Toxic Glucosinolate Derivatives from Rapeseed Meal by Intestinal Microflora of Rat and Chicken, J. Sci. Food Agric, 1988, 43, 299-308.
Effects of 1-Isothiocyanato-3-(Methylsulfinyl)-Propane on Xenobiotic Metabolizing Enzymes in Rats, Fd. Chem. Toxic., vol. 31, No. 10, pp. 723-729, 1993.
Effect of Organic Reducing Agents and Ferrous Ion on Thioglucosidase Activity of Crambe Abyssinica Seed, Canadian Journal of Biochemistry, vol. 48, 1970.
Rapid Detection of Inducers of Enzymes that Protect Against Carcinogens, Proc. Natl. Acad. Sci. USA 89 (1992).
Influence of Some Management Parameters on Glucosinolate Levels in Brassica Forage, Agronomy Journal, vol. 77, Jul.-Aug. 1985.
Distribution and Metabolism of the Natural Anticarcinogen Phenethyl Isothiocynate in A/J Mice, Carcinogenesis, vol. 11, No. 11, pp. 2033-2036, 1990.
Anticarcinogenic Activities of Sulforaphane and Structurally Related Synthetic Norbornyl Isothiocyanates, Proc. Natl. Acad. Sci., USA 91, (1994).
1-Cyano-3, 4-Epithiobutane: A Major Product of Glucosinolate Hydrolysis in Seeds From Certain Varieties of Brassica Campestris, Phytochemistry, 1974, col. 13, pp. 2611-2615.
Nutrients and Toxicants in Rapeseed Meal: A Review, Journal of Animal Science, vol. 58, No. 4, 1984.
Myrosinase Activity of Cruciferous Vegetables, Sci. Food Agric., 1984, 35, 543-552.
Detoxification of Commercial United Kingdom Rapeseed Meal by Glucosinolate Hydrolysis with Exogenous Myrosinase and the Extractability of the Aglucones by Aqueous Industrial Methylated Spirits, J. Sci. Food Agric., 1989, 46, 331-337.
A Major Inducer of Anticarcinogenic Protective Enzymes From Broccoli: Isolation and Elucidation of Structure, Proc. Natl. Acad. Sci., USA, 89 (1992).
Methods for Glucosinolate Analysis, Methods in Plant Biochemistry, vol. 8, ISBN 0-12-461018-8, 1993.
Aspects on the Use of Headspace GC On-Column Injections in Flavor Research, Journal of Chromatographic Science, vol. 26, Nov. 1988.
High-Performance Liquid Chromatographic Analysis of Anticarcinogenic Indoles in Brassica Oleracea, J. Agric. Food Chem. 1987, 35, 46-49.
Separation of Desulphoglucosinolates by Reversed-Phase High-Performance Liquid Chromatography, Journal of Chromatography, 247 (1982), 141-148.
Study on Volatile Isothiocyanate Detected in Cultivar of Brassica Vegetable (Part 2) Analysis of Flavour of Cabbage by Gas-Chromatography-Mass Spectrometry, (Rept. Natl. Food Res. Inst.) No. 47, 41-48 (1985).
HPLC Separation of Glucosinolates from Leaves and Seeds of Arabidopis Thaliana and Their Identification Using Thermospray Liquid Chromatography/Mass Spectrometry, Journal of Chromatographic Science, vol. 26, Nov. 1988.
Purification of the w-(Methylsulfinyl)alkyl Glucosinolate Hydrolysis Products: 1-Isothiocyanato-3-(Methylsulfinyl)Propane, 1-Isothiocyanato-4-(Methylsulfinyl)Butane, 4-(Methylsulfinyl)Butanenitrile, and 5-(Methylsulfinyl)Pentanenitrile from Broccoli and Lesquerella Fendleri, J. Agric. Food Chem., 1993, 41, 89-95.
Glucosinolates in Rapeseeds: Analytical Aspects, Proceedings of a Seminar in the CEC Programme of Research on Plant Producitivity, held in Gembloux (Belgium), 1-3 Oct. 1986.
GCIRC Eighth International Rapeseed Congress, vol. 5 of 6, Jul. 1991.
Formation of Organic Nitriles from Progoitrins in Leaves of Crambe Abyssinica and Brassica Napus, J. Agr. Food Chem., vol. 19, No. 1, 1971.
Goitrogenic Activity of Allylisothiocyanate--A Widespread Natural Mustard Oil, vol. 76, Jan. 1965.
Glucosinolates and Derived Products in Cruciferous Vegetables. Identification of Organic Nitriles from Cabbage, J. Agric. Food Chem., vol. 25, No. 1, 1977.
Effect of Organic Reducing Agents and Ferrous Ion on Thioglucosidase Activity of Crambe Abyssinica Seed, Canadian Journal of Biochemistry, vol. 48, 1970.
Isolation and Identification of Trans-4-(Methylthio)-3-Butenyl Glucosinolate from Radish Roots (Raphanus Sativus L.), J. Agric. Food Chem., 1992, 40, 1687-1691.
In Vitro Activity of Some Glucosinolates and Their Reaction Products Toward a Population of the Nematode Heterodera Schachtii, J. Agric. Food Chem., 1993, 41, 825-829.
Glucosinolates and Derived Products in Cruciferous Vegetables. Analysis of the Edible Part from Twenty-Two Varieties of Cabbage, J. Agric. Food Chem., vol. 24, No. 3, 1976.
Glucosinolate Products in Commercial Sauerkraut, J. Agric. Food Chem., 1980, 28, 809-811.
Identification and Quantification of Organosulfur Compliance Mark in a Garlic Extract, J. Agric. Food Chem., 1993, 41, 37-41.
Journal of Agricultural Research, vol. 67, Jul. 1-Dec. 15, 1943.
Volatile Isothiocyanates and Nitriles from Glucosinolates in Rutabaga and Turnip, J. Amer. Soc. Hort. Sci. 107(6):1050-1054, 1982.
High-Performance Liquid Chromatography and Gas Chromatography of Organic Isothiocyanates and their Methanol-Isothiocyanate Addition Compounds, Journal of Chromatography, 155 (1978) 198-202.
Dimeric Structure of a Sulfoxide, Journal of the American Chemical Society, 87:3, Feb. 5, 1965.
Isothiocyanates XIV, 5-Methylthiopentyl Isothiocyanate, a New Mustard Oil Present in Nature as a Glucoside (Glucoberteroin), Acta Chem. Scand. 9 (1955) No. 8.
Collection of Czechoslovak Chemical Communications, 5, XXIV, 1959.
Isothiocyanates XXX. Glucohirsutin, a New Naturally Occurring Glucoside Furnishing (-)-8-Methylsulphinyl-Octyl Isothiocyanate on Enzymic Hydrolysis, Acta Chem. Scand. 12 (1958) No. 5.
Isothiocyanates VIII, Synthesis of p-Hydroxybenzyl Isothiocyanate and Demonstration of its Presence in the Glucoside of White Mustard (Sinapis alba L.), Acta Chem. Scand. 8 (1954) No. 4.
Absorption Spectra of Alkyl Isothiocyanates and N-Alkyl Monothiocarbamates, Acta Chem. Scand. 13 (1959) No. 3.
Progress in the Chemistry of Organic Natural Products, 1960.
1994 IFT Annual Meeting/Book of Abstracts, p. 217, 72-6.
Beyond Vitamins, Newsweek, Apr. 25, 1994, pp. 45-49.
Elevation of Serum Phase II Enzymes by Anticarcinogenic Enzyme Inducers: Makers for a Chemoprotected State? pp. 2441-2445, 1993.
Cancer Chemoprevention by Phytochemicals in Fruits and Vegetables, Chapter 1, 1994.
The Biology and Chemistry of the Cruciferae, Academic Press, 1976, pp. 191-205.
Cancer Preventive Properties of Varieties of Brassica Oleracea: A Review, Am. J. Clin. Nutr., 1994, pp. 1166-1170.
Chiang William C.
Letiz Richard E. A.
Pusateri Donald J.
Sperrazzo Phelicia M.
Amway Corporation
Page Thurman K.
Spear James M.
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