Branched polymers and their conjugates

Details Branched polymers and their conjugates Branched polymers and their conjugates

2006-04-11

2006-04-11

Wilson, James O. (Department: 1623)

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

From heterocyclic reactant containing as ring atoms oxygen,...

C528S406000, C514S429000, C435S006120

Reexamination Certificate

active

07026440

ABSTRACT:
The present invention is directed to branched reactive water-soluble polymers comprising at least two polymer arms, such as poly(ethylene glycol), attached to a central aliphatic hydrocarbon core molecule through heteroatom linkages. The branched polymers bear at least one functional group for reacting with a biologically active agent to form a biologically active conjugate. The functional group of the branched polymer can be directly attached to the aliphatic hydrocarbon core or via an intervening linkage, such as a heteroatom, -alkylene-, —O-alkylene-O—, -alkylene-O-alkylene-, -aryl-O—, —O-aryl-, (—O-alkylene-)m, or (-alkylene-O—)mlinkage, wherein m is 1–10.

REFERENCES:
patent: 5122614 (1992-06-01), Zalipsky
patent: 5605976 (1997-02-01), Martinez et al.
patent: 5643575 (1997-07-01), Martinez et al.
patent: 5681567 (1997-10-01), Martinez et al.
patent: 5681811 (1997-10-01), Ekwuribe
patent: 5684096 (1997-11-01), Taylor et al.
patent: 5756593 (1998-05-01), Martinez et al.
patent: 5874500 (1999-02-01), Rhee et al.
patent: 5919455 (1999-07-01), Greenwald et al.
patent: 5932462 (1999-08-01), Harris et al.
patent: 6113906 (2000-09-01), Greenwald et al.
patent: 6258351 (2001-07-01), Harris
patent: 6348558 (2002-02-01), Harris et al.
patent: 6362254 (2002-03-01), Harris et al.
patent: 6497895 (2002-12-01), Uhrich
patent: 2002/0052443 (2002-05-01), Greenwald et al.
patent: 0899310 (1999-03-01), None
patent: 3067541 (2000-07-01), None
patent: WO 94/26778 (1994-11-01), None
patent: WO 01/49268 (2001-07-01), None
patent: WO 02/060978 (2002-08-01), None
Choi et al., “Star-Shaped Poly(ether-ester) Block Copolymers: Synthesis, Characterization, and Their Physical Properties”,Macromolecules, 1998, pp. 8766-8774, vol. 31, No. 25.
Schmalenberg et al., “Cytotoxicity of a Unimolecular Polymeric Micelle and Its Degradation Products”,Biomacromolecules, 2001, pp. A-E.

Affiliated with

Also associated with

Rating

Branched polymers and their conjugates does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Branched polymers and their conjugates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Branched polymers and their conjugates will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3592414