Branched polymers and their conjugates

Details Branched polymers and their conjugates Branched polymers and their conjugates

2011-01-18

2011-01-18

Jiang, Shaojia Anna (Department: 1623)

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

C525S054200, C564S506000, C568S062000

Reexamination Certificate

active

07872072

ABSTRACT:
The present invention is directed to branched reactive water-soluble polymers comprising at least two polymer arms, such as poly(ethylene glycol), attached to a central aliphatic hydrocarbon core molecule through heteroatom linkages. The branched polymers bear at least one functional group for reacting with a biologically active agent to form a biologically active conjugate. The functional group of the branched polymer can be directly attached to the aliphatic hydrocarbon core or via an intervening linkage, such as a heteroatom, -alkylene-, —O-alkylene-O—, -alkylene-O-alkylene-, -aryl-O—, —O-aryl-, (—O-alkylene-)m, or (-alkylene-O—)mlinkage, wherein m is 1-10.

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