Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Reexamination Certificate
2007-10-23
2009-06-16
Shiao, Rei-Tsang (Department: 1626)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
C424S078270, C525S054100, C548S546000, C549S417000
Reexamination Certificate
active
07547765
ABSTRACT:
The present invention provides a branched polyalkylene glycol wherein three or more single-chain polyalkylene glycols and a group having reactivity with an amino acid side chain, the N-terminal amino group or the C-terminal carboxyl group in a polypeptide or a group convertible into the group having reactivity are bound; and a physiologically active polypeptide modified with the branched polyalkylene glycol.
REFERENCES:
patent: 3553254 (1971-01-01), Tesoro et al.
patent: 5342940 (1994-08-01), Ono et al.
patent: 5643575 (1997-07-01), Martinez et al.
patent: 5698529 (1997-12-01), Alakhov et al.
patent: 5767284 (1998-06-01), Sanchika et al.
patent: 5807971 (1998-09-01), Gozzini et al.
patent: 5872191 (1999-02-01), Sanchika et al.
patent: 5919455 (1999-07-01), Greenwald et al.
patent: 5932462 (1999-08-01), Harris et al.
patent: 6111048 (2000-08-01), Asahina et al.
patent: 2002/0120096 (2002-08-01), Tsuchida et al.
patent: 2003/0219404 (2003-11-01), Yamasaki et al.
patent: 0 400 486 (1990-12-01), None
patent: 0 839 849 (1998-05-01), None
patent: 0 809 996 (1999-04-01), None
patent: 1153088 (1989-06-01), None
patent: 2000-191700 (2000-07-01), None
patent: 95/11924 (1995-05-01), None
patent: 97/10281 (1997-03-01), None
patent: 99/22770 (1999-05-01), None
patent: 99/45964 (1999-09-01), None
patent: 99/55377 (1999-11-01), None
patent: 01/48052 (2001-07-01), None
Conforti, et al., “PEG Superoxide Dismutase Derivatives: Anti-Inflammatory Activity in Carrageenan Pelurisy in Rats”, Pharmacological Research Communications, vol. 19, No. 4 (1987) 287-94.
Yamasaki, et al., “Modification of Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF) and Its Derivative ND 28 with Polyethylene Glycol”, J. Biochem, vol. 115, No. 5, (1994) 814-19.
Ahern, et al., Stability of Protein Pharmaceuticals, Part B, Pharmaceutical Biotechnology, vol. 3, “PEG-Modified Proteins” (1992) 235-63.
Ohno, “Polymer-Modification and Polymer Solvent for the Protein Stabilization”, Dept. Of Biotechnology, Tokyo University of Agriculture and Technology, vol. 38, No. 5 (1998) 208-10.
Inada, et al, “Ester Synthesis Catalyzed by Polyethylene Glycol-Modified Lipase in Benzene”, Biochemical and Biophysical Research Communications, vol. 122, No. 2 (1984) 845-50.
Zalipsky, “Functionalized Poly(ethylene glycol) for Preparation of Biologically Relevant Conjugates”, Bioconjugate Chem. vol. 6, No. 2 (1995) 150-65.
Campbell, et a, Pegylated Peptides V, Journal of Peptide Research, vol. 49, (1997) 527-37.
Goodson, et al., “Site-directed Pegylation of Recombinant Interleukin-2 at its Glycosylation Site”, Bio/Technology, vol. 8 (1990) 343-46.
Knauf, et al. “Relationship of Effective Molecular Size to Systemic Clearance in Rats of Recombinant Interleukin-2 Chemically Modified with Water-soluble Polymers”, the Journal of Biological Chemistry, vol. 263, No. 29 (1988) 15064-70.
Pettit, et al., “Structure-Function Studies of Interleukin 15 Using Site-Specific Mutagenesis, Polyetheylene Glycol Conjugation, and Homology Modeling”, The Journal of Biological Chemistry, vol. 272, No. 4, (1997) 2312-18.
Zeuzem, et al. “Peginterferon alfa-2a (40 kDa) monotherapy: a novel agent for chronic hepatitis C therapy”, Expert Opin. Investig. Drugs, vol. 12 (2001) 2201-13.
Motzer, et al., “Phase I Trial of 40-kd Branched Pegylated Interferon alfa-2a for Patients With Advanced Renal Cell Carcinoma”, Journal of Clinical Oncology, vol. 19, No. 5 (2001) 1312-19.
Kuwabara Takashi
Mukai Mayumi
Murakami Tatsuya
Sukurai Noriko
Suzawa Toshiyuki
Fitzpatrick ,Cella, Harper & Scinto
Kosack Joseph R
Kyowa Hakko Kirin Co., Ltd.
Shiao Rei-Tsang
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