Branched immunomodulatory compounds and methods of using the...

Details Branched immunomodulatory compounds and methods of using the... Branched immunomodulatory compounds and methods of using the...

2003-12-17

2009-12-01

Nickol, Gary B. (Department: 1648)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S045000, C514S048000, C514S049000, C514S885000, C424S001110, C424S001730, C424S001770, C424S278100, C424S280100, C536S022100, C536S023100, C536S025600

Reexamination Certificate

active

07625872

ABSTRACT:
The invention provides immunomodulatory compounds and methods for immunomodulation of cells and individuals using the immunomodulatory compounds.

REFERENCES:
patent: 4458066 (1984-07-01), Caruthers et al.
patent: 4849513 (1989-07-01), Smith et al.
patent: 4910300 (1990-03-01), Urdea et al.
patent: 4948882 (1990-08-01), Ruth
patent: 5015733 (1991-05-01), Smith et al.
patent: 5093232 (1992-03-01), Urdea et al.
patent: 5118800 (1992-06-01), Smith et al.
patent: 5118802 (1992-06-01), Smith et al.
patent: 5124246 (1992-06-01), Urdea et al.
patent: 5171264 (1992-12-01), Merrill et al.
patent: 5359100 (1994-10-01), Urdea et al.
patent: 5391723 (1995-02-01), Priest
patent: 5453496 (1995-09-01), Caruthers et al.
patent: 5460831 (1995-10-01), Kossovsky et al.
patent: 5484596 (1996-01-01), Hanna, Jr. et al.
patent: 5545730 (1996-08-01), Urdea et al.
patent: 5571677 (1996-11-01), Gryaznov
patent: 5578717 (1996-11-01), Urdea et al.
patent: 5580731 (1996-12-01), Chang et al.
patent: 5591584 (1997-01-01), Chang et al.
patent: 5594117 (1997-01-01), Urdea et al.
patent: 5594118 (1997-01-01), Urdea et al.
patent: 5597909 (1997-01-01), Urdea et al.
patent: 5614622 (1997-03-01), Iyer et al.
patent: 5681940 (1997-10-01), Wang et al.
patent: 5703218 (1997-12-01), Urdea et al.
patent: 5710264 (1998-01-01), Urdea et al.
patent: 5712378 (1998-01-01), Wang
patent: 5830658 (1998-11-01), Gryaznov
patent: 5849481 (1998-12-01), Urdea et al.
patent: 5886165 (1999-03-01), Kandimalla et al.
patent: 6077668 (2000-06-01), Kool
patent: 6117657 (2000-09-01), Usman et al.
patent: 6191266 (2001-02-01), Wang
patent: 6194388 (2001-02-01), Krieg et al.
patent: 6207646 (2001-03-01), Krieg et al.
patent: 6235465 (2001-05-01), Kolberg et al.
patent: 2002/0028784 (2002-03-01), Van Nest
patent: 2003/0175731 (2003-09-01), Fearon
patent: 0 313 219 (1989-04-01), None
patent: 81 267 (2000-08-01), None
patent: WO 89/02439 (1989-03-01), None
patent: WO 89/03891 (1989-05-01), None
patent: WO 97/28259 (1997-08-01), None
patent: WO 98/16247 (1998-04-01), None
patent: WO 98/55495 (1998-12-01), None
patent: WO 99/11275 (1999-03-01), None
patent: WO 99/62923 (1999-12-01), None
patent: WO 00/61151 (2000-10-01), None
patent: WO 01/22972 (2001-04-01), None
patent: WO 01/35991 (2001-05-01), None
patent: WO 01/68077 (2001-09-01), None
patent: WO 01/68144 (2001-09-01), None
patent: WO-03/057822 (2003-07-01), None
patent: WO-03/057822 (2003-07-01), None
patent: WO-03/057822 (2003-07-01), None
Klinman et al (1999) Vaccine. 17: 19-25.
Winfree et al (1998) Nature. 394:539-544.
Shchepinov et al (1999) Nucleic Acids Research. 27(15): 3035-3041.
Yu et al (2001) Bioorganic and Medicinal Chemistry. 9: 2803-2808.
Liang et al (2000) Journal of Immunology. 165: 1438-1445.
Yu et al (2002) J. Med. Chem. 45: 4540-4548.
Yu et al (2002) Nucleic Acids Research 30(20): 4460-4469.
Grotli et al (1997) Tetrahedron 53(33): 11317-11346.
Sonehara et al (1996) J. of Interferon and Cytokine Research. 16: 799-803.
Agrawal, Sudhir et al. (1986). “Efficient Methods for Attaching Non-Radioactive Labels to the 5′ ends of Synthetic Oligodeoxyribonucleotides,”Nucleic Acids Res. 14(15):6227-6245.
Ahmeida, E.T.S. Ben et al. (1993). “Immunopotentiation Local and Systemic Humoral Immune Responses by ISCOMs, Liposomes and FCA: Role In Protection Against Influenza A In Mice,”Vaccine11:1302-1309.
Altmann et al. (1995). “NMR Studies of DNA Duplexes Singly Cross-linked by Different Synthetic Linkers,”Nucleic Acids Research23:4827-4835.
Aramaki,Yukihito et al. (1995). “Interferon-? inductive Effect of Liposomes as an Immunoadjuvant,”Vaccine13:1809-1814.
Asanuma et al. (1995). “Cross-Protection Against Influenza Virus Infection in Mice Vaccinated by Combined Nasal-Subcutaneous Administration,”Vaccine13(1):3-5.
Atherton et al. (1981). “Synthesis of a 21-Residue Fragment of Human Proinsulin by the Polyamide Solid Phase Method,”Hoppe Seylers Z. Physiol. Chem. 362:833-839.
Ballas, Zuhair et al. (1996). “Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynulceotides and bacterial DNA,”J. Immunol. 157:1840-1845.
Bartley et al. (1997). “Solution Conformation of an Intramolecular DNA Triplex Containing a Nonnucleotide Linker: Comparison with the DNA Duplex,”Biochemistry36:14502-14511.
Beaucage. (1993). “Oligodeoxyribonucleotide Synthesis” in Protocols for Oligonucleotides and Analogs, Synthesis and Properties (Agrawal, ed.) Humana Press, Totowa, NJ, pp. 33-61.
Benoit, Robert et al. (1987). “Peptides. Strategies for Antibody Production and Radioimmunoassays,” inNeuromethods, Alan A. Boulton et al., eds., Humana Press, Clifton, NJ: pp. 43-72.
Bischoff, Rainer et al. (1987). “Introduction of 5′-Terminal Functional Groups into Synthetic Oligonucleotides for Selective Immobilization,”Analytical Biochemistry164:336-344.
Blanks et al. (1988). “An Oligodeoxynucleotide Affinity Column for the Isolation of Sequence Specific DNA Binding Proteins,”Nucleic Acids Res. 16:10283-10299.
Bohle Barbara et al. (1999) “Oligodeoxynucleotides containing CpG Motifs Induce IL-12, IL-18 and IFN-y Production in Cells from Allergic Individuals and Inhibit IgE Synthesis in Vitro,”Eur. J. Immunol. 29:2344-2353.
Boujrad et al. (1993) “Inhibition of Hormone-Stimulated Steroidogenesis in Cultured Leydig Tumor Cells by a Cholesterol-Linked Phosphorothioate Oligodeoxynucleotide Antisense to Diazepam-Binding Inhibitor,”Biochemistry90:5728-5731.
Bousquet et al. (1999). “Molecular Mechanisms of the Adsorption of a Model Protein (Human Serum Albumin) on Poly(Methylidene malonate 2.1.2) Nanoparticles,”Pharm. Res. 16:141-147.
Braich et al. (1997). “Regiospecific Solid-Phase Synthesis of Branched Oligonucleotides. Effect of Vicinal 2′,5′-(or 2′,3′-) and 3′,5′-Phosphodiester Linkages on the Formation of Hairpin DNA,”Bioconjugate Chem. 8(3):370-377.
Braun et al. (1988). “Immunogenic Duplex Nucleic Acids are Nuclease Resistant,”J. Immunol. 141(5):2084-2089.
Breiteneder et al. (1989). “The Gene Coding for the Major Birch Pollen Allergen Betvl, is highly homologous to a Pea Disease Resistance Response Gene,”EMBO J. 8:1935-1938.
Chaturvedi et al. (1996). “Stabilization of Triple-Stranded Oligonucleotide Complexes: Use of Probes Containing Alternating Phosphodiester and Stereo-Uniform Cationic Phosphoramidate Linkages,”Nucleic Acids Res. 24(12):2318-2323.
Chavany et al. (1992). “Polyalkylcyanoacrylate Nanoparticles as Polymeric Carriers for Antisense Oligonucleotides,”Pharm. Res. 9:441-449.
Chavany et al. (1994). “Adsorption of Oligonucleotides onto Polyisohexylcyanoacrylate Nanoparticles Protects Them Against Nucleases and Increases Their Cellular Uptake,”Pharm. Res. 11:1370-1378.
Chen et al. (1999). “Enhanced Protection Against a Lethal Influenza Virus Challenge by Immunization With Both Hemagglutinin- and Neuraminindase-expressing DNAs,” Vaccine 17:653-659.
Cho, Hearn Jay et al. (2000). “Immunostimulatory DNA-Based Vaccines Induce Cytotoxic Lymphocyte Activity by a T-Helper Cell-Independent Mechanism,”Nature Biotechnol. 18:509-514.
Chua et al. (1988). “Sequence Analysis of cDNA Coding For a Major House Dust Mite Allergen, Der p. 1,”J. Exp. Med. 167:175-182.
Chua et al. (1990). “Expression of Dermatophagoides Pteronyssinus Allergen, Der p. II, inEscherichia coliand the Binding Studies with Human IgE,”Int. Arch. Allergy Appl. Immunol. 91:124-129.
Cload et al. (1991). “Polyether Tethered Oligonucleotide Probes,”J. Am. Chem. Soc. 113:6324-6326.
Connolly (1985). “Chemical Synthesis of Oligonucleotides Containing a Free Sulphydryl Group and Subsequent Attachmentof Thiol Specific Probes,”Nucleic Acids Res. 13:4485-4502.
Connolly (1987). “The Synthesis of Oligonucleotides Containing a

Affiliated with

Also associated with

Rating

Branched immunomodulatory compounds and methods of using the... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Branched immunomodulatory compounds and methods of using the..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Branched immunomodulatory compounds and methods of using the... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4055365