Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1992-09-15
1996-12-10
Woodward, Michael P.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
530324, 530325, 530326, 530327, 530328, 4241891, 4242281, C12Q 170, C07K 17089, A61K 3929
Patent
active
055829686
ABSTRACT:
The present invention relates to novel branched peptides specific for the diagnosis and prevention of non-A, non-B hepatitis (NANBH), as well as hepatitis C virus (HCV) infection. More particularly, the present invention is directed to branched synthetic substituted and hybrid peptides containing at least one epitope which is effective in detecting NANBH-associated antibodies in patients with NANBH using immunoassay techniques. In addition, this invention provides immunoassays for the detection and diagnosis of NANBH using the subject peptides, vaccine compositions for prevention and treatment of NANBH or HCV infection as well as a method of treating or preventing NANBH and HCV infection.
REFERENCES:
patent: 5106726 (1992-04-01), Wang
patent: 5191064 (1993-03-01), Arima et al.
patent: 5229490 (1993-07-01), Tam
patent: 5229491 (1993-07-01), Habets et al.
S allberg et al., "Immune Response to a Single Peptide . . . ", Immunol Lett 33:27-34 (1992).
Houghten et al., "The Use of Synthetic Peptide Combinatorial . . . ," Biotechniques 13:412-421 (1992).
Geysen et al., "Cognitive Features of Continuous Antigenic . . . ," J Molec Recognition 1:32-41 (1988).
Farci et al., "Lack of Protective Immunity Against Reinfection . . . ", Science 258:135-140 (1992).
Kuo et al, (1989) Science 244:362-364, An Assay for Circulating Antibodies to a Major Etiologic Virus of Human Non-A, Non-B Hepatitis.
Arima, et al, (1989) Gastroenterologia Japonica 24:540-544 Cloning of a cDNA associated with acute and chronic hepatitis C infection generated from patients serum RNA.
Arima et al, (1989) Gastroenterologica Japonica 24:545-548 A lambda gt11-cDNA clone specific for chronic hepatitis C generated from pooled serum presumably infected by hepatitis C virus.
Maeno et al, (1990) Nucleic Acid Research 18:2685-2689 A cDNA clone closely associated with non-A, non-B hepatitis.
Reyes et al, (1990) Science 247:1335-1339 Isolation of cDNA from the Virus Responsible for Enterically Transmitted Non-A, Non-B Hepatitis.
Okamoto et al, (1990) Japan J. Exp. Med. 60:167-177 The 5'-Terminal Sequence of the Hepatitis C Virus Genome.
Kato et al, (1990) Proc. Natl. Acad. Sci. 87:9524-9528 Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis.
Mishiro et al, (1990) Lancet 336:1400-1403 Non-A, Non-B hepatitis specific antibodies directed at host-derived epitope: implication for an autoimmune process.
Hosein et al, (1991) Proc. Natl. Acad. Sci. 88:3647-3651 Improved serodiagnosis of hepatitis C virus infection with synthetic peptide antigen from capsid protein.
Okamoto et al, (1992) J. Gen. Virology 73:673-679 Typing hepatitis C virus by polymerase chain reaction with type-specific primers: application to clinical surveys and tracing infectious sources.
Hosein Barbara H.
Wang Chang-Yi
United Biomedical Inc.
Woodward Michael P.
LandOfFree
Branched hybrid and cluster peptides effective in diagnosing and does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Branched hybrid and cluster peptides effective in diagnosing and, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Branched hybrid and cluster peptides effective in diagnosing and will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-423113