Branched histidine copolymers and methods for using same

Details Branched histidine copolymers and methods for using same Branched histidine copolymers and methods for using same

2006-07-04

2006-07-04

Priebe, Scott D. (Department: 1633)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

C435S320100, C435S458000, C514S002600, C514S04400A, C530S300000, C530S323000, C530S324000, C424S486000

Reexamination Certificate

active

07070807

ABSTRACT:
The invention provides a branched transport polymer characterized as having at least 10 amino acids and a ratio of histidine to non-histidine amino acids greater than 1.5, said branched transport polymer comprising one or more backbones, one or more terminal branches, and optionally, one or more non-terminal branches. The branched transport polymer may be associated with a pharmaceutical agent to form a pharmaceutical agent delivery composition useful for in vivo therapies based on local injection.

REFERENCES:
patent: 4847240 (1989-07-01), Ryser et al.
patent: 5354844 (1994-10-01), Beug et al.
patent: 5554388 (1996-09-01), Illum
patent: 5670347 (1997-09-01), Gopal
patent: 5736392 (1998-04-01), Hawley-Nelson et al.
patent: 5856435 (1999-01-01), Bazile et al.
patent: 5985354 (1999-11-01), Mathiowitz et al.
patent: 6051429 (2000-04-01), Hawley-Nelson et al.
patent: 6312727 (2001-11-01), Schacht et al.
patent: 6372499 (2002-04-01), Midoux et al.
patent: 6692911 (2004-02-01), Pack et al.
patent: 0 727 223 (1995-04-01), None
patent: WO 98/22610 (1998-05-01), None
patent: WO 99/42091 (1999-08-01), None
patent: WO 00/32764 (2000-06-01), None
Midoux et al., Membrane Permeabilization and Efficient Gene Transfer by a Peptide Containing Several Histindines.Bioconjug Chem98, 9, 260-267.
Midoux et al., Efficient Gene Transfer by Histidylated Polylysine/pDNA Complexes.Bioconjugate ChemMay-Jun. 1999; 10(3):4-6-411.
Chen et al., Co-polymer of histidine and lysine markedly enhances transfection efficiency of liposomes.Gene TherOct 2000; 7(19):1698-1705.
Chen et al., Branched co-polymers of histidine and lysine are efficient carriers of plasmids.Nucleic Acids ResMar. 15, 2001; 29(6):1334-1340.
Pichon et al., Histidylated oligolysines increase the transmembrane passage and the biological activity of antisense oligonucleotides.Nucleic Acids ResJan. 15, 2000; 28(2):504-512.
Putnam et al., Polymer-based gene delivery with low cytotoxicity by a unique balance of side-chain termini.Proc Natl Acad Sci USAJan 30; 98(3):1200-1205.

Affiliated with

Also associated with

Rating

Branched histidine copolymers and methods for using same does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Branched histidine copolymers and methods for using same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Branched histidine copolymers and methods for using same will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3607975