Branched cationic copolymers and methods for antimicrobial use

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C530S329000

Reexamination Certificate

active

07465708

ABSTRACT:
The invention provides a branched copolymer for the treatment of bacterial, fungal, and viral infections. The branched copolymer is characterized as having (i) at least 10 amino acids, (ii) at least 10% of the amino acids are histidine, (iii) at least 10% of the amino acids are non-histidine, (iv) said branched polymer comprising one or more backbones, (v) one or more terminal branches, and (vi) optionally, one or more non-terminal branches.

REFERENCES:
patent: 4847240 (1989-07-01), Ryser et al.
patent: 5354844 (1994-10-01), Beug et al.
patent: 5554388 (1996-09-01), Illum et al.
patent: 5670347 (1997-09-01), Gopal
patent: 5736392 (1998-04-01), Hawley-Nelson et al.
patent: 5856435 (1999-01-01), Bazile et al.
patent: 5912230 (1999-06-01), Oppenheim et al.
patent: 5985354 (1999-11-01), Mathiowitz et al.
patent: 6051429 (2000-04-01), Hawley-Nelson et al.
patent: 6113946 (2000-09-01), Szoka, Jr. et al.
patent: 6312727 (2001-11-01), Schacht et al.
patent: 6372499 (2002-04-01), Midoux et al.
patent: 6475004 (2002-11-01), Shuey et al.
patent: 6692911 (2004-02-01), Pack et al.
patent: 7070807 (2006-07-01), Mixson
patent: 7163695 (2007-01-01), Mixson
patent: 2001/0006817 (2001-07-01), Pack et al.
patent: 0 727 223 (1996-08-01), None
patent: WO-98/22610 (1998-05-01), None
patent: WO-99/42091 (1999-08-01), None
patent: WO-00/32764 (2000-06-01), None
patent: WO-01/47496 (2001-07-01), None
Midoux et al., Membrane Permeabilization and Efficient Gene Transfer by a Peptide Containing Several Histidines.Bioconjugate Chem98, 9, 260-267.
Midoux et al., Efficient Gene Transfer by Histidylated Polylysine/pDNA Complexes.Bioconjugate ChemMay-Jun. 1999; 10(3):406-411.
Chen et al., Co-polymer of histidine and lysine markedly enhances transfection efficiency of liposomes.Gene TherOct. 2000; 7(19):1698-1705.
Chen et al., Branched co-polymers of histidine and lysine are efficient carriers of plasmids.Nucleic Acids ResMar. 15, 2001; 29(6):1334-1340.
Pichon et al., Histidylated oligolysines increase the transmembrane passage and the biological activity of antisense oligonucleotides.Nucleic Acids ResJan. 15, 2000; 28(2):504-512.
Putnam, D. et al., Polymer-based gene delivery with low cytotoxicity by a unique balance of side-chain termini.PNAS98(3), Jan. 30, 2001, pp. 1200-1205.
Bechinger, B., Kinder, R., Helmle, M., Voogt, T.C., Harzer, U. and Schinzel, S. (1999). Peptide structural analysis by solid-state NMR spectroscopy.Biopolymers51, 174-90.
Bellm, L., Lehrer, R. J. and Ganz, T. (2000). Protegrins: new antibiotics ofmammalian origin.Expert Opin Investig Drugs9, 1731-42.
Blanc, E., Fremont, V., Sizun, P., Meunier, S., Van Rietschoten, J., Thevand, A., Bemassau, J.M. and Darbon, H. (1996). Solution structure of PO1, a natural scorpion peptide structurally analogous to scorpion toxins specific for apamin- sensitive potassium channel.Proteins24, 359-69.
Bontems, F., Roumestand, C., Gilquin, B., Menez, A. and Toma, F. (1991). Refined structure of charybdotoxin: common motifs in scorpion toxins and insect defensins.Science254, 1521-3.
Chen, Q.R., Zhang, L., Stass, S.A. and Mixson, A.J. (2001). Branched co-polymers of histidine and lysine are efficient carriers of plasmids.Nucleic Acids Res.29, 1334-1340.
Cruz, L.J., Johnson, D.S. and Olivera, B.M. (1987). Characterization of the omega-conotoxin target. Evidence for tissue-specific heterogeneity in calcium channel types.Biochemistry26, 820-4.
Dathe, M. and Wieprecht, T. (1999). Structural features of helical antimicrobial peptides: their potential to modulate activity on model membranes and biological cells.Biochim Biophys Acta1462, 71-87.
Epand, R.M. and Vogel, H.J. (1999). Diversity of antimicrobial peptides and their mechanisms of action.Biochim Biophys Acta1462, 11-28.
Giacometti, A., Cirioni, O., Ghiselli, R., Viticchi, C., Mocchegiani, F., Riva, A., Seba, V. and Scalise, G. (2001). Effect of mono-dose intraperitoneal cecropins in experimental septic shock.Crit Care Med29, 1666-9.
Gilles, M., Krimm, J., Bouet, F., Froy, O., Gurevitz, M., Lancelin, J.M. and Gordon, D. (2000). Structural implications on the interaction of scorpion alpha-like toxins with the sodium channel receptor site inferred from toxin iodination and pH-dependent binding.J Neurochem75, 1735-45.
Hancock, R.E. (1997). Peptide antibiotics.Lancet349, 418-22.
Hancock, R.E. (1999). Host defense (cationic) peptides: what is their future clinical potential?Drugs57, 469-73.
Hancock, R.E. and Lehrer, R. (1998). Cationic peptides: a new source of antibiotics.Trends Biotechno16, 82-8.
Harder, J., Bartels, J., Christophers, E. and Schroder, J.M. (2001). Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic.J Biol Chem276, 5707-13.
Hoover, D.M., Chertov, O. and Lubkokwski, J. (2001). The structure of human beta-defensin-1: new insights into structural properties of beta-defensins.J Biol Chem276, 39021-6.
Hughes, A.L. (1999). Evolutionary diversification of the mammalian defensins.Cell Mol Life Sci56, 94-103.
Jia, H.P., Mllls, J.N., Barahmand-Pour, F., Nishimura, D., Mallampali, R.K., Wang G., Wiles, K., Tack, B.F., Bevins, C.L. and McCray, P.B., Jr. (1999). Molecular cloning and characterization of rat genes encoding homologues of human beta-defensins.Infect Immun67, 4827-33.
Kourie, J.I. and Shorthouse, A.A. (2000). Properties of cytotoxic peptide-formed ion channels.Am J Physiol Cell Physiol278, C1063-87.
La Rocca, P., Biggin, P.C., Tieleman, D.P. and Sansom, M.S. (1999). Simulation studies of the interaction of antimicrobial peptides and lipid bilayers.Biochim Biophys Acta1462, 185-200.
Lehrer, R.I. and Ganz, T. (1996). Endogenous vertebrate antibiotics. Defensins, protegrins, and other cysteine-rich antimicrobial peptides.Ann NY Acad Sci797, 228-39.
Mallow, E.B., Harris, A., Salzman, N., Russell, J.P., DeBerardinis, R.J., Ruchelli, E. and Bevins, C.L. (1996). Human enteric defensins. Gene structure and developmental expression.J Biol Chem271, 4038-45.
Martin, M.F. and Rochat, H. (1984). Purification of thirteen toxins active on mice from the venom of the North African scorpionButhus occitanus tunetanus. Toxicon22, 279-91.
Mosca, D.A., Hurst, M.A., So, W., Viajar, B.S., Fujii, C.A. and Falla, T.J. (2000). IB-367, a protegrin peptide with in vitro and in vivo activities against the microflora associated with oral mucositis.Antimicrob Agents Chemother44, 1803-8.
Oppenheim, F.G., Xu, T., McMillian, F.M., Levitz, S.M., Diamond, R.D., Offner, G.D. and Troxler, R.F. (1988b). Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects onCandida albicans. J Biol Chem263, 7472-7.
Oppenheim, F.G., Xu, T., McMillian, F.M., Levitz, S.M., Diamond, R.D., Offner, G.D. and Troxler, R.F. (1988a). Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects onCandida albicans. J Biol Chem263, 7472-7.
Oren, Z., Lerman, J.C., Gudmundsson, G.H., Agerberth, B. and Shai, Y. (1999). Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: relevance to the molecular basis for its non-cell-selective activity.Biochem J341, 501-13.
Oren, Z. and Shai, Y. (1998). Mode of action of linear amphipathic alpha-helical antimicrobial peptides.Biopolymers47, 451-63.
Oren, Z., Ramesh, J., Avrahami, D., Suryaprakash, N., Shai, Y. and Jelinek, R. (2002), Structures and mode of membrane interaction of a short alpha helical lytic peptide and its diastereomer determined by NMR, FTIR, and fluorescence spectroscopy,Eur J Biochem269, 3869-80.
Otvos, L, Jr. (2000). Antibacterial peptides isolated from insects.J Pept Sci6, 497-511.
Otvos, L., Jr., Bokonyi, K., Varga, L, Otvos, B.I., Hoffmann, R., Ertl, H.C., Wade, J.D., McManus, A.M., Craik, D.J. and Bulet, P. (2000). Insect peptides with improved protease-resistance protect mice against bacterial infection.Protein Sci9, 742-9.
Peschel, A. and Collins, L.V. (2001). Staphylococcal resistance to antimicrobial peptides of mammalian and

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