Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 4 to 5 amino acid residues in defined sequence
Patent
1988-08-03
1991-07-23
Lee, Lester L.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
4 to 5 amino acid residues in defined sequence
530331, 530332, C07K 508, C07K 510
Patent
active
050345125
ABSTRACT:
The invention concerns a novel series of renin-inhibitory branched-backbone peptides which are useful for treating renin associated hypertension, congestive heart failure, and hyperaldosteronism. Processes for preparing the peptides, compositions containing them and methods of using them are included. Also included is a diagnostic test using the compounds to determine the presence of renin-associated hypertension, congestive heart failure, or hyperaldosteronism.
REFERENCES:
patent: 4839357 (1989-06-01), Patchett et al.
Burger, Medicinal Chemistry, 1960, pp. 565-571, 578-581, 600-601.
Denkewalter et al., Progress In Drug Research, 1966, pp. 510-512.
Plattner et al., J. Med. Chem., 1988, 31(12), pp. 2277-2288.
Hudspeth James P.
Kaltenbronn James S.
Repine Joseph T.
Sircar Ila
Anderson Elizabeth M.
Lee Lester L.
Maebius Stephen B.
Warner-Lambert & Company
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