Brain-specific analogues of centrally acting amines

Details Brain-specific analogues of centrally acting amines Brain-specific analogues of centrally acting amines

1988-06-20

1990-06-12

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

546316, C07H 1524

Patent

active

049334387

ABSTRACT:
The subject compounds, which are adapted for the site-specific/sustained delivery of centrally acting drug species to the brain, are compounds of the formula ##STR1## and the non-toxic pharmaceutically acceptable salts thereof, wherein D is the residue of a centrally acting primary, secondary or tertiary amine and ##STR2## is an unsubstituted or substituted dihydropyridyl, dihydroquinolyl or dihydroisoquinolyl radical. The corresponding ionic pyridinium, quinolinium and isoquinolinium salts ##STR3## wherein X.sup.- is the anion of a non-toxic pharmaceutically acceptable acid, are also disclosed.

REFERENCES:
patent: 4314054 (1982-02-01), Acton et al.
patent: 4479932 (1984-10-01), Bodor
Chemical Abstracts, vol. 84, June 7, 1976, p. 447, abstract No. 164580z.
Chemical Abstracts, vol. 81, Aug. 5, 1974, p. 24, abstract No. 20899a.

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