Brain-specific analogues of centrally acting amines

Details Brain-specific analogues of centrally acting amines Brain-specific analogues of centrally acting amines

1991-09-27

1994-03-22

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514214, 540586, 546141, 546142, 546145, 546146, 546147, 546150, 546152, 546153, 546296, 546297, 546299, A61K 3155, C07D40106

Patent

active

052964833

ABSTRACT:
The subject compounds, which are adapted for the site-specific/sustained delivery of centrally acting drug species to the brain, are compounds of the formula ##STR1## and the non-toxic pharmaceutically acceptable salts thereof, wherein D is the residue of a centrally acting primary, secondary or tertiary amine and ##STR2## is an unsubstituted or substituted dihydropyridyl, dihydroquinolyl or dihydroisoquinolyl radical. The corresponding ionic pyridinium, quinolinium and isoquinolinium salts ##STR3## wherein X.sup.- is the anion of a non-toxic pharmaceutically acceptable acid, are also disclosed.

REFERENCES:
Thiel, et al., "Chemical Abstracts", vol. 59, 1963, Col. 6389e-6391a.

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