Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-04-04
1992-01-21
Fan, Jane T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514345, 514307, 514309, 514311, 514312, 514348, 514350, 514354, 514356, 514357, 514358, 546316, 546322, 546326, 546296, 546297, 546301, 546302, 546332, 546329, 546342, 546298, 546299, 546300, 546155, 546156, 546157, 546158, 546141, 546142, 546145, 546146, 546147, 546150, 546152, 546153, A61K 3144, C07D21190
Patent
active
050828533
ABSTRACT:
The subject compounds, which are adapted for the site-specific/sustained delivery of centrally acting drug species to the brain, are compounds of the formula ##STR1## and the non-toxic pharmaceutically acceptable salts thereof, wherein D is the residue of a centrally acting primary, secondary or tertiary amine and ##STR2## is an unsubstituted or substituted dihydropyridyl, dihydroquinolyl or dihydroisoquinolyl radical. The corresponding ionic pyridinium, quinolinium and isoquinolinium salts ##STR3## wherein X.sup.- is the anion of a non-toxic pharmaceutically acceptable acid, are also disclosed.
REFERENCES:
patent: 4479932 (1984-10-01), Bodor
Dean et al., CA 86:16522h.
Chemical Abstracts, vol. 84, Jun. 7, 1976, p. 447, abstract No. 164580z.
Chemical Abstracts, vol. 81, Aug. 5, 1974, p. 24, abstract No. 20899a.
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