Surgery – Means for introducing or removing material from body for... – Gas application
Patent
1993-06-01
1995-03-07
Grieb, William H.
Surgery
Means for introducing or removing material from body for...
Gas application
604 28, 604 52, A61M 2100
Patent
active
053953142
ABSTRACT:
The invention discloses a method for preserving organs in brain-dead humans or cadavers which allows additional time for the organs to remain viable such that they may be harvested for subsequent transplantation. The method includes the steps of catheterizing the vessels or tissues around the organ sought to be preserved, introducing a temperature controlled solution to cool the organ to inhibit degenerative metabolism, oxygenating the organ and inhibiting free radicle damage. The temperature controlled organ preservation solution includes perfluorocarbons, antioxidants, tissue damage reversing and protecting agents, carrier vehicles, diluents, nutrients, and anti-coagulating agents. A device which performs this method is also disclosed. This device includes a fluid reservoir, an oxygen tank, a heat exchanger and removable catheter lines. Also disclosed is a method for brain resuscitation involving injections of "warm" resuscitation solution followed by injection of "cool" and oxygenated resuscitation solution.
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"Use of Extracorporeal Cadaver Perfusion for Preparation of Organ Homografts", by T. L. Marchioro, M.D., William R. Waddell, M.D., F.A.C.S., and Thomas E. Starzl, M.D., F.A.C.S., Surgical Forum, vol. XIV American College of Surgeons. Chicago, Ill., 1963, pp. 174-176.
"Extracorporeal Perfusion for Obtaining Postmortem Homografts", by T. L. Marchioro, M.D., R. T. Huntley, B.S., W. R. Waddell, M.D., T. E. Starzl, M.D. PhD, Surgery, vol. 54, Jul.-Dec., 1963 pp. 900-911.
"In Situ Kidney Preservation for Transplantation with Use of Profound Hypothermia (5 to 20 C.) with an Intact Circulation", Surgery, vol. 79, No. 1, Jan. 1976, pp. 60-64.
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Goldman Robert M.
Klatz Ronald M.
Grieb William H.
Life Resuscitation Technologies, Inc.
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