Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ether doai
Patent
1989-11-17
1991-06-25
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ether doai
514721, A01N 3114
Patent
active
050267337
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The present invention relates to a brain function-improving medicine.
BACKGROUND ART
Currently, the number of people more than 55 years old comprises more than 10% of the total population of this country, and thus it is considered that the number of patients suffering from dementia will greatly increase with the inevitable increase of the number of old people in the population, whereby serious problems will arise due to the increase in the number of patients suffering from dementia, the burden on families having to attend to such patients, and the necessity for an increase in the number of medical institutions.
Accordingly, the development of brain function-improving medicines such as psychotropic drugs and dementia-curing agents is urgently required.
As a medicine for remedy of schizophrenia, namely a psychotropic drug, Haloperidol, Chlorpromazine and Tetrabenazine are used.
These medicines, however, have adverse side effects such as a reduction of the learning function, and thus the administration of these medicines is limited, and therefore, a satisfactory medicinal effect cannot be obtained thereby.
DISCLOSURE OF THE INVENTION
The present inventors investigated various pharmacognostic components with a view to developing a medicine not showing an effect of reducing the learning function but exerting excellent psychotropic and anti-dementia effects, and as the result, found that a compound represented by the following formula: ##STR2## which is an extract component of the crude drug "Shizandra chinensis", has not only an excellent psychotropic action but also an excellent anti-dementia 1 action. The present invention was completed based on this finding.
More specifically, in accordance with the present invention, there is provided a brain function-improving medicine comprising a compound represented by the following formula (hereinafter referred to as "compound of the formula"): ##STR3## as an effective ingredient.
BEST MODE OF CARRYING OUT THE INVENTION
The compound of the formula can be obtained, for example, by the process disclosed in [Y. Ikeya, H. Taguchi, I. Yoshioka and H. Kobayashi, Chem. Pharm. Bull., 27(6), 1383 (1979)].
More specifically, "Shizandra chinensis" is extracted in a warm state with a lower hydrocarbon such as petroleum ether, n-hexane or benzene, the solvent is removed from the extract, and the residue is dissolved in water and subjected to steam distillation to remove an essential oil. The obtained non-essential-oil component is subjected to chromatography using a silica gel, and the development is carried out by using n-hexane, benzene, acetone or a mixture thereof to obtain the intended compound.
A specific example of the preparation of the compound of the formula will now be described.
SPECIFIC EXAMPLE
A product obtained by pulverizing 1.38 kg of "Shizandra chinensis" was refluxed and extracted with 3l of petroleum ether, and this extraction was conducted four times. The extracts were combined, and the petroleum ether was removed under reduced pressure to obtain 188 g of a petroleum ether extract. This extract was suspended in 450 ml of water and the suspension was subjected to steam distillation for 3 hours to remove an essential oil. The residue was extracted with 200 ml of ether 4 times, the ether extracts were combined, and the ether was removed to obtain 179 g of a petroleum ether-soluble non-essential-oil portion (hereinafter referred to as "fraction A").
Then, "Shizandra chinensis" extracted with petroleum ether was extracted in a warm state with 3 l of methanol for 3 hours, and this extraction was conducted 3 times. The methanol extracts were combined and the mixture was concentrated to obtain 383 g of a methanol extract. This extract was dissolved in 580 ml of water and the solution was subjected to shaking extraction with 850 ml of ethyl acetate 3 times. The ethyl acetate extracts were combined and concentrated under reduced pressure to obtain 78 g of an extract. The extract was dissolved in methanol and 300 g of Celite 535 (supplied by J
Hosoya Eikichi
Ishige Atsushi
Itoh Kouichi
Craires Theodore I.
Friedman Stanley J.
Tsumura & Co.
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