Brain endothelial cell protein induced by nerve growth factor

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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530350, 514 2, A61K 3800, A61K 3803, C07K 1447

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active

056772777

ABSTRACT:
The present invention provides a novel isolated and purified protein that is produced by brain endothelial cells, has a molecular weight of approximately 67 kDa of SDS-PAGE, with the protein being capable of stimulating proliferation of cerebral arteriole smooth muscle cells. Also provided are various methods of using this novel protein or the gene encoding this protein, including methods of treating various cerebrovascular diseases.

REFERENCES:
Lillieu et al Nature 317 632-634 (1985).
Cordon-Cardo et al Cell 66 173-184 (1991).
Ikedo et al Brain Res 649 260-264 (1994).

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