Brain-derived neurotrophic factor

Details Brain-derived neurotrophic factor Brain-derived neurotrophic factor

1989-08-30

1993-01-19

Lacey, David L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 691, 435 693, 4351723, 4353201, 530399, 530412, C12P 2106, C12N 1500, A61K 3724, C07H 1512

Patent

active

051808200

ABSTRACT:
The present invention relates to nucleic acid sequences encoding brain derived neurotrophic factor (BDNF), as well as BDNF protein produced in quantity using these nucleic acid sequences, as well as fragments and derivatives thereof. In addition, the invention relates to pharmacologic compositions and therapeutic uses of BDNF, having provided, for the first time, the ability to generate sufficient quantities of substantially pure BDNF for clinical use. The invention also relates to antibodies directed toward BDNF or fragments thereof, having provided a method for generating sufficient immunogen. Further, by permitting a comparison of the nucleic acid sequences of BDNF and NGF, the present invention provides for the identification of homologous regions of nucleic acid sequence between BDNF and NGF, thereby defining a BDNF/NGF gene family; the invention provides a method for identifying an disolating additional members of this gene family.

REFERENCES:
patent: 4935370 (1990-07-01), Franke
patent: 4945046 (1990-07-01), Horii et al.
Barde et al. (1982) The EMBO Jounal, vol. 5, pp. 549-553.
Hofer et al., (Jan. 1988) Nature, vol. 331, pp. 261-262.
Walz et al, (1987) Biochemical and Biophysical Research Communications vol. 149, pp. 755-761.
Wion et al. (1986) FEBS Letters, vol. 203, pp. 82-86.
Jaenisch (Jun. 10, 1988) Science, vol. 240. pp. 1468-2474.
Hofer and Barde, Nature 331:261-262 (1988).
Rodrigeuz-Tebar and Barde, J. Neurosci. 8(9):3337-3342 (1988).
Barde et al., Prog. Brain Res. 71:185-189 (1987).
Davies et al., Nature 319: 497-499 (1986).
Lindsay and Rohrer, Dev. Biol. 112: 30-48 (1985).
Barde et al., Ann. Rev. Physiol. 45: 601-612 (1983).
Barde et al., EMBO J. 1(5): 549-553 (1982).
Lindsay and Tarbit, Neurosci. Lett. 12: 195-200 (1979).
Thanos et al., 1989, Eur. J. Neurosci. 1: 19-26.
Kalcheim and Gendreau, 1988, Develop. Brain Res. 41: 79-86.
Lindsay, 1988, J. Neurosci. 8:2394-2405.
Kalcheim et al., 1987, EMBO J. 6:2871-2873.
Davies et al., 1986, J. Neurosci. 6:1897-1904.
Johnson et al., 1986, J. Neurosci. 6:3031-3038.
Kalcheim & LeDouarin, 1986, Develop. Biol. 116:451-466.
Barde & Thoenen, "1985 in Hormones and Cell Regulation", vol. 9, Dumont et al., eds., Elsevier Science Publishers, pp. 385-390.
Davies and Lindsay, 1985, Develop. Biol. 111:62-72.
Lindsay et al., 1985, J. Cell. Sci. Supp. 3:115-129.
Lindsay & Rohrer, 1985, Develop. Biol. 112:30-48.
Lindsay et al., 1985, Develop. Biol. 112:319-328.
Lindsay & Peters, 1984, Neurosci. 12:45-51.
Pearson et al., 1983, Develop. Biol. 96:32-36.
Sarthy et al., 1983, J. Neurosci. 3:2532-2544.
Turner et al., 1983, Dev. Brain Res. 6:77-83.
Lindsay et al., 1982, Brain Res. 243:329-343.
McCaffery et al., 1982, Exp. Brain Res. 48:377-386.
Barde et al., 1980, PNAS 77:1199-1203.
Johnson et al., 1980, Science 210:916-918.
Lindsay, 1979, Nature 282:80-82.
Barde et al., 1978, Nature 274:818.
Levi-Montalcini, 1966, The Harvey Lectures 60:217-259.

Affiliated with

Also associated with

Rating

Brain-derived neurotrophic factor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Brain-derived neurotrophic factor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Brain-derived neurotrophic factor will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-102924