Brain derivable polypeptide factors and antibodies thereto

Details Brain derivable polypeptide factors and antibodies thereto Brain derivable polypeptide factors and antibodies thereto

1986-01-27

1990-10-16

Nocker, Christine

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

436501, 436518, 436536, 436547, 436548, 436815, 514 2, 514 12, 514 13, 514 14, 514 15, 514 16, 514 17, 530324, 530325, 530326, 530327, 530328, 530329, 530387, G01N 3353, A61K 3718

Patent

active

049634852

ABSTRACT:
Novel polypeptides, polynucleotide sequences, DNA constructs and compositions are provided for the preparation and use of polypeptides associated with naturally occurring polypeptides found in brains. The low molecular weight polypeptides either are growth inhibitors for neoplastic cells without inhibiting normal cells or affect GABA-ergic transmission. The polypeptides find use in inhibiting neoplastic growth, modulating diazepam receptor response, and detecting receptors for the polypeptides. Antibodies are provided in conjunction with the polypeptides, which may be used together or separately for detecting the presence of the polypeptides.

REFERENCES:
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Webb et al, "Bovine and Human cDNA Sequences Encoding a Putative Benzo-diazepine Receptor Ligand", DNA (1987) 71-79.

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