Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1999-03-04
2000-11-14
Ford, John M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544 44, 544 46, A61K 31485, C07D49108
Patent
active
061470848
ABSTRACT:
The present invention relates to a novel brain cell protective agent having for its active ingredient a morphinan derivative represented with Compound 1 ##STR1## or pharmacologically acceptable acid addition salt thereof. The compounds used in the present invention were found to have excellent defensive effects against brain nerve cell necrosis in both in vitro and in vivo pharmacological evaluations, and can be used as useful preventive and therapeutic agents of ischemic brain disorders, brain nerve cell disorders and dementia.
REFERENCES:
patent: 3819635 (1974-06-01), Pachter
patent: 4241067 (1980-12-01), Kobyecki et al.
patent: 4267182 (1981-05-01), Holaday et al.
patent: 4362870 (1982-12-01), Portoghese
patent: 4401672 (1983-08-01), Portoghese
patent: 4767718 (1988-08-01), Meyers
patent: 4806556 (1989-02-01), Portoghese
patent: 4816586 (1989-03-01), Portoghese
patent: 4906637 (1990-03-01), Faden
patent: 4925848 (1990-05-01), Lewis
patent: 5219861 (1993-06-01), Kanematsu
patent: 5556838 (1996-09-01), Mayer et al.
patent: 5739145 (1998-04-01), Nagase et al.
patent: 5834448 (1998-11-01), Ito
patent: 5852030 (1998-12-01), Nagase et al.
Schoenecker et al., "Opioid Agonist and . . . ", J. Med. Chem., vol. 30, No. 5, pp. 933-935 (1987).
Lyeth et al., Chemical Abstr, vol. 123, Entry 133374 (1995).
Nactase et al., Chemical Abstr, vol. 123, Entry 9747, abstracting WO 95-03308 (1995).
Lyeth et al., Neuropeptides, vol. 29, pp. 11-19 (1995).
Endo Takashi
Imamura Yoshifumi
Matsuda Susumu
Miyauchi Yasushi
Nagase Hiroshi
Ford John M.
Toray Industries Inc.
LandOfFree
Brain cell protective agent does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Brain cell protective agent, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Brain cell protective agent will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2065701