Brain-associated inhibitor of tissue-type plasminogen activator

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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435 697, 4352523, 4353201, 435325, 536 231, 536 235, C12P 2106, C12N 1500, C12N 500, C07H 2104

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active

060080205

ABSTRACT:
The present invention relates to a novel BAIT protein which is a member of serpin superfamily which is expressed primarily in brain tissue. In particular, isolated nucleic acid molecules are provided encoding the human BAIT protein. BAIT polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of BAIT activity. Also provided are diagnostic methods for detecting nervous system-related disorders and therapeutic methods for treating nervous system-related disorders.

REFERENCES:
patent: 5700924 (1997-12-01), Braxton
Osterwalder et al., (1996) EMBO Journal 15:2944-2953.

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