Bradykinin cyclic analog-cyclo-[(N.sup..epsilon. -1-L-lysine, 6-

Details Bradykinin cyclic analog-cyclo-[(N.sup..epsilon. -1-L-lysine, 6- Bradykinin cyclic analog-cyclo-[(N.sup..epsilon. -1-L-lysine, 6-

1978-12-08

1980-02-05

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, C07C10352, C07G 700

Patent

active

041872177

ABSTRACT:
Cyclic analog of bradykinin having the formula ##STR1## where Lys-L-lysine residue, Pro-L-proline residue, Gly-glycine residue, Phe-L-phenylalanine residue, Arg-L-arginine residue. The present compound can create prolonged depressor effect in experiments in vivo, as well as increase vascular permeability in experiment in situ less than bradykinin. In experiments in vitro this compound displays no myotropic effect.

REFERENCES:
patent: 3216991 (1965-11-01), Ondetti et al.
patent: 3216993 (1965-11-01), Bodanszky et al.
patent: 3256267 (1966-06-01), Boissonnas et al.

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